Kalirin mediates Rac1 activation downstream of calcium/calmodulin‐dependent protein kinase II to stimulate glucose uptake during muscle contraction
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14428
Abstract: In this study, we investigated the role of calcium/calmodulin‐dependent protein kinase II (CaMKII) in contraction‐stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to… read more here.
Keywords: contraction; muscle; kinase; calcium calmodulin ... See more keywords
Neurospora casein kinase 1a recruits the circadian clock protein FRQ via the C‐terminal lobe of its kinase domain
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DOI: 10.1002/1873-3468.14435
Abstract: Timing by the circadian clock of Neurospora is associated with hyperphosphorylation of frequency (FRQ), which depends on anchoring casein kinase 1a (CK1a) to FRQ. It is not known how CK1a is anchored so that approximately… read more here.
Keywords: circadian clock; neurospora casein; frq; kinase ... See more keywords
Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14505
Abstract: Ack1 is a proto‐oncogenic tyrosine kinase with homology to the tumour suppressor Mig6, an inhibitor of the epidermal growth factor receptor (EGFR). The residues critical for binding of Mig6 to EGFR are conserved within the… read more here.
Keywords: kinase; mig6; activity; homology ... See more keywords
An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP‐dependent protein kinase A
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14610
Abstract: The cAMP‐dependent protein kinase A (PKA) is the archetypical eukaryotic kinase. The catalytic subunit (PKA‐C) structure is highly conserved among the AGC‐kinase family. PKA‐C is a bilobal enzyme with a dynamic N‐lobe, harbouring the Adenosine‐5′‐triphosphate… read more here.
Keywords: cooperativity; protein kinase; kinase; camp dependent ... See more keywords
Paclitaxel induces apoptosis through the TAK1–JNK activation pathway
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DOI: 10.1002/2211-5463.12917
Abstract: Paclitaxel (PTX) has previously been used to treat tumours of various tissue origins, such as lung, breast, ovarian, prostate cancers and leukemia. PTX‐induced apoptosis is associated with p38 mitogen‐activated protein kinase (p38 MAPK), extracellular signal‐regulated… read more here.
Keywords: apoptosis; jnk; cleavage; tak1 ... See more keywords
Overexpression of TRAF4 promotes lung cancer growth and EGFR‐dependent phosphorylation of ERK5
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DOI: 10.1002/2211-5463.13458
Abstract: Tumor necrosis factor receptor‐associated factor 4 (TRAF4) is overexpressed in a variety of carcinomas of different origins, but its role in tumorigenesis remains incompletely understood. Previous studies suggest that TRAF4 promotes epidermal growth factor receptor… read more here.
Keywords: lung cancer; kinase; phosphorylation erk5; traf4 promotes ... See more keywords
A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51491
Abstract: Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS). This first‐in‐human study investigated… read more here.
Keywords: dual leucine; zipper kinase; kinase; gdc 0134 ... See more keywords
Myotonic dystrophy kinase‐related CDC42‐binding kinase α, a new transferrin receptor type 2‐binding partner, is a regulator of erythropoiesis
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DOI: 10.1002/ajh.26104
Abstract: Efficient erythropoiesis relies on the expression of the transferrin receptor type 2 (TFR2). In erythroid precursors, TFR2 facilitates the export of the erythropoietin receptor (EPOR) to cell surface, which ensures the survival and proliferation of… read more here.
Keywords: kinase; transferrin receptor; receptor type; myotonic dystrophy ... See more keywords
Deoxynucleoside Therapy for Thymidine Kinase 2–Deficient Myopathy
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DOI: 10.1002/ana.25506
Abstract: Thymidine kinase 2, encoded by the nuclear gene TK2, is required for mitochondrial DNA maintenance. Autosomal recessive TK2 mutations cause depletion and multiple deletions of mtDNA that manifest predominantly as a myopathy usually beginning in… read more here.
Keywords: deficient myopathy; kinase; kinase deficient; deoxynucleoside therapy ... See more keywords
Computational modelling and invitro evaluation identified natural product - Z218 as a novel Janus Kinase-2 (JAK2) inhibitor to combat Beta Thalassemia.
Sign Up to like & getrecommendations! Published in 2023 at "Biotechnology and applied biochemistry"
DOI: 10.1002/bab.2459
Abstract: Aberrant activity of Janus kinase 2 (JAK2) is a known driver of several myeloproliferative disorders, including polycythemia Vera, and Thalassemia. Several inhibitors have been proposed to inhibit JAK2 activity in order to control the disease… read more here.
Keywords: kinase jak2; kinase; jak2; natural product ... See more keywords
Engineering soluble artificial epidermal growth factor receptor mimics capable of spontaneous in vitro dimerization
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DOI: 10.1002/bit.27659
Abstract: Epidermal growth factor receptor (EGFR) is a clinically validated target for a multitude of human cancers. The receptor is activated upon ligand binding through a critical dimerization step. Dimerization can be replicated in vitro by… read more here.
Keywords: dimerization; kinase; factor receptor; growth factor ... See more keywords