Kalirin mediates Rac1 activation downstream of calcium/calmodulin‐dependent protein kinase II to stimulate glucose uptake during muscle contraction
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14428
Abstract: In this study, we investigated the role of calcium/calmodulin‐dependent protein kinase II (CaMKII) in contraction‐stimulated glucose uptake in skeletal muscle. C2C12 myotubes were contracted by electrical pulse stimulation (EPS), and treadmill running was used to… read more here.
Keywords: contraction; muscle; kinase; calcium calmodulin ... See more keywords
Neurospora casein kinase 1a recruits the circadian clock protein FRQ via the C‐terminal lobe of its kinase domain
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DOI: 10.1002/1873-3468.14435
Abstract: Timing by the circadian clock of Neurospora is associated with hyperphosphorylation of frequency (FRQ), which depends on anchoring casein kinase 1a (CK1a) to FRQ. It is not known how CK1a is anchored so that approximately… read more here.
Keywords: circadian clock; neurospora casein; frq; kinase ... See more keywords
Activity of the nonreceptor tyrosine kinase Ack1 is regulated by tyrosine phosphorylation of its Mig6 homology region
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DOI: 10.1002/1873-3468.14505
Abstract: Ack1 is a proto‐oncogenic tyrosine kinase with homology to the tumour suppressor Mig6, an inhibitor of the epidermal growth factor receptor (EGFR). The residues critical for binding of Mig6 to EGFR are conserved within the… read more here.
Keywords: kinase; mig6; activity; homology ... See more keywords
An NMR portrait of functional and dysfunctional allosteric cooperativity in cAMP‐dependent protein kinase A
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DOI: 10.1002/1873-3468.14610
Abstract: The cAMP‐dependent protein kinase A (PKA) is the archetypical eukaryotic kinase. The catalytic subunit (PKA‐C) structure is highly conserved among the AGC‐kinase family. PKA‐C is a bilobal enzyme with a dynamic N‐lobe, harbouring the Adenosine‐5′‐triphosphate… read more here.
Keywords: cooperativity; protein kinase; kinase; camp dependent ... See more keywords
Binding mechanism of adenylate kinase‐specific monobodies
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DOI: 10.1002/1873-3468.70076
Abstract: Monobodies are synthetic antibody‐mimetic proteins that regulate enzyme functions through protein–protein interactions. In this study, we investigated the binding mechanisms of monobodies to adenylate kinase (Adk). Calorimetric and X‐ray crystallographic analyses revealed that CL‐1, a… read more here.
Keywords: adenylate kinase; specific monobodies; kinase specific; mechanism adenylate ... See more keywords
ERK1/2 mitogen‐activated protein kinase dimerization is essential for the regulation of cell motility
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DOI: 10.1002/1878-0261.13732
Abstract: ERK1/2 mitogen‐activated protein kinases (ERK) are key regulators of basic cellular processes, including proliferation, survival, and migration. Upon phosphorylation, ERK becomes activated and a portion of it dimerizes. The importance of ERK activation in specific… read more here.
Keywords: cell motility; kinase; dimerization; erk1 mitogen ... See more keywords
Paclitaxel induces apoptosis through the TAK1–JNK activation pathway
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DOI: 10.1002/2211-5463.12917
Abstract: Paclitaxel (PTX) has previously been used to treat tumours of various tissue origins, such as lung, breast, ovarian, prostate cancers and leukemia. PTX‐induced apoptosis is associated with p38 mitogen‐activated protein kinase (p38 MAPK), extracellular signal‐regulated… read more here.
Keywords: apoptosis; jnk; cleavage; tak1 ... See more keywords
Overexpression of TRAF4 promotes lung cancer growth and EGFR‐dependent phosphorylation of ERK5
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DOI: 10.1002/2211-5463.13458
Abstract: Tumor necrosis factor receptor‐associated factor 4 (TRAF4) is overexpressed in a variety of carcinomas of different origins, but its role in tumorigenesis remains incompletely understood. Previous studies suggest that TRAF4 promotes epidermal growth factor receptor… read more here.
Keywords: lung cancer; kinase; phosphorylation erk5; traf4 promotes ... See more keywords
A Phase 1 study of GDC‐0134, a dual leucine zipper kinase inhibitor, in ALS
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DOI: 10.1002/acn3.51491
Abstract: Dual leucine zipper kinase (DLK), which regulates the c‐Jun N‐terminal kinase pathway involved in axon degeneration and apoptosis following neuronal injury, is a potential therapeutic target in amyotrophic lateral sclerosis (ALS). This first‐in‐human study investigated… read more here.
Keywords: dual leucine; zipper kinase; kinase; gdc 0134 ... See more keywords
Discovery of a Novel Pseudo‐Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling
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DOI: 10.1002/advs.202309202
Abstract: The pseudo‐natural product (pseudo‐NP) concept aims to combine NP fragments in arrangements that are not accessible through known biosynthetic pathways. The resulting compounds retain the biological relevance of NPs but are not yet linked to… read more here.
Keywords: natural product; morphological profiling; aurora kinase; kinase ... See more keywords
LIMK1 as a Novel Kinase of β‐Catenin Promotes Esophageal Cancer Metastasis by Cooperating With CDK5
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DOI: 10.1002/advs.202503223
Abstract: Metastasis is a major cause of cancer deaths, but the underlying molecular mechanisms remain largely unknown. Esophageal squamous cell carcinoma (ESCC) is a highly aggressive cancer with poor survival, yet the key kinases driving ESCC… read more here.
Keywords: cancer; catenin; cdk5; limk1 ... See more keywords