Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5-a]pyrimidine-Based Macrocycles.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00173
Abstract: Serine/threonine kinase 17A (death-associated protein kinase-related apoptosis-inducing protein kinase 1─DRAK1) is a part of the death-associated protein kinase (DAPK) family and belongs to the so-called dark kinome. Thus, the current state of knowledge of the… read more here.
Keywords: threonine kinase; pyrazolo pyrimidine; kinase 17a; kinase ... See more keywords
Serine Threonine Kinase 17A Maintains the Epithelial State in Colorectal Cancer Cells
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DOI: 10.1158/1541-7786.mcr-18-0990
Abstract: Serine threonine kinase 17A (STK17A) is a ubiquitously expressed kinase originally identified as a regulator of apoptosis; however, whether it functionally contributes to colorectal cancer has not been established. Here, we have analyzed STK17A in… read more here.
Keywords: threonine kinase; serine threonine; cancer; kinase 17a ... See more keywords