On-chip dual enzyme activity assay to investigate regulation of the transamidase and kinase activities of transglutaminase 2.
Sign Up to like & getrecommendations! Published in 2018 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2018.04.021
Abstract: Transglutaminase 2 (TGase2), a multifunctional enzyme exhibiting both transamidase and kinase activity, is involved in a variety of cellular processes and diseases. However, details of the regulation of TGase2 have not been reported due to… read more here.
Keywords: enzyme activity; kinase activities; kinase; transamidase kinase ... See more keywords
Nitroxide Tempol down-regulates kinase activities associated with NADPH oxidase function in phagocytic cells and potentially decreases their fungicidal response.
Sign Up to like & getrecommendations! Published in 2018 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2017.11.016
Abstract: AIMS The identification of novel targets to control inflammation in humans is probably the primary challenge that impairs the development of new anti-inflammatory drugs. Therefore, the modulation of intracellular signaling pathways in phagocytes may be… read more here.
Keywords: tempol regulates; response; kinase activities; regulates kinase ... See more keywords
Multiplexing the Quantitation of MAP Kinase Activities Using Differential Sensing.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12757
Abstract: Protein kinases are therapeutic targets for many human diseases, but the lack of user-friendly quantitative assays limits the ability to follow the activities of numerous kinases at once (multiplexing). To develop such an assay, we… read more here.
Keywords: kinase activities; differential sensing; kinase; map kinase ... See more keywords
Transport and kinase activities of CbrA of Pseudomonas putida KT2440
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-62337-9
Abstract: The CbrA/CbrB system is a two-component signal transduction system known to participate in the regulation of the cellular carbon/nitrogen balance and to play a central role in carbon catabolite repression in Pseudomonas species. CbrA is… read more here.
Keywords: transport kinase; kinase activities; kinase; transport ... See more keywords