SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway
Sign Up to like & getrecommendations! Published in 2024 at "Inflammation Research"
DOI: 10.1007/s00011-024-01913-5
Abstract: Microglia, the main innate immune cells in the central nervous system, are key drivers of neuroinflammation, which plays a crucial role in the pathogenesis of neurodegenerative diseases. The Sin3/histone deacetylase (HDAC) complex, a highly conserved… read more here.
Keywords: ask1 p38; expression upstream; upstream kinase; kinase ask1 ... See more keywords
Abstract 22: Apoptosis Signal-Regulating Kinase 1 (ASK1) is a Novel Master Molecular Switch Controlling Microglia/Macrophage Reactions That Impact Short- and Long-Term Stroke Outcomes
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DOI: 10.1161/str.50.suppl_1.22
Abstract: Introduction: Recent studies suggest that the functional status of microglia/macrophages (Mi/MΦ) profoundly impacts stroke outcome. However, the molecular mechanisms regulating Mi/MΦ reactions afte... read more here.
Keywords: kinase ask1; apoptosis signal; ask1 novel; regulating kinase ... See more keywords