RIPK1 Kinase-Dependent Death: A Symphony of Phosphorylation Events.
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DOI: 10.1016/j.tcb.2019.12.009
Abstract: The serine/threonine kinase RIPK1 has emerged as a crucial component of the inflammatory response activated downstream of several immune receptors, where it paradoxically functions as a scaffold to protect the cell from death or instead… read more here.
Keywords: death; kinase; kinase dependent; ripk1 kinase ... See more keywords
RIP kinase 1–dependent endothelial necroptosis underlies systemic inflammatory response syndrome
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DOI: 10.1172/jci96147
Abstract: Receptor interacting protein kinase 1 (RIPK1) has important kinase-dependent and kinase-independent scaffolding functions that activate or prevent apoptosis or necroptosis in a cell context–dependent manner. The kinase activity of RIPK1 mediates hypothermia and lethality in… read more here.
Keywords: tnf; kinase; necroptosis; inflammatory response ... See more keywords
A kinase‐dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion
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DOI: 10.15252/embr.201744737
Abstract: Sister‐chromatid cohesion mediated by the cohesin complex is fundamental for precise chromosome segregation in mitosis. Through binding the cohesin subunit Pds5, Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin… read more here.
Keywords: cohesin; centromere cohesion; cohesion; kinase dependent ... See more keywords