Profiling of small-molecule necroptosis inhibitors based on the subpockets of kinase-ligand interactions.
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DOI: 10.1002/med.21968
Abstract: Necroptosis is a highly regulated cell death (RCD) form in various inflammatory diseases. Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 are involved in the pathway. Targeting the kinase domains of RIPK1 and/or 3 is a… read more here.
Keywords: necroptosis; kinase ligand; kinase domains; kinase ... See more keywords