Small-Molecule Kinase Downregulators.
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DOI: 10.1016/j.chembiol.2017.10.011
Abstract: New opportunities to advance small-molecule kinase ligands that downregulate their cognate target binding proteins are discussed. Rationally designed heterobifunctional kinase degraders are compared with ATP site ligands that were serendipitously found to cause kinase downregulation.… read more here.
Keywords: molecule kinase; kinase; kinase downregulators; small molecule ... See more keywords