Mechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-49499-0
Abstract: Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as a mechanism of resistance to targeted therapy. Partner genes and exons in most TK fusions are followed typical recurrent patterns,… read more here.
Keywords: clinical implications; fusion; tyrosine kinase; targeted therapy ... See more keywords
ETV6-NTRK3 and STRN-ALK kinase fusions are recurrent events in papillary thyroid cancer of adult population.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of endocrinology"
DOI: 10.1530/eje-17-0499
Abstract: OBJECTIVE PTC-specific analysis identified novel fusions involving RET, BRAF, NTRK1, NTRK3, AGK and ALK genes in adults and pediatric PTCs. Although many novel fusions are PTC-specific events and, therefore, are ideal for diagnosis purposes, validation… read more here.
Keywords: etv6 ntrk3; alk; kinase fusions; ptc ... See more keywords