The pivotal role of glycogen synthase kinase 3 (GSK-3) in vomiting evoked by specific emetogens in the least shrew (Cryptotis parva)
Sign Up to like & getrecommendations! Published in 2019 at "Neurochemistry international"
DOI: 10.1016/j.neuint.2019.104603
Abstract: Glycogen synthase kinase 3 (GSK-3) is a constitutively active multifunctional serine-threonine kinase which is involved in diverse physiological processes. GSK-3 has been implicated in a wide range of diseases including neurodegeneration, inflammation, diabetes and cancer.… read more here.
Keywords: glycogen synthase; kinase; kinase gsk; synthase kinase ... See more keywords
Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-b]pyridazines as Glycogen Synthase Kinase-3β (GSK-3β) Inhibitors.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00133
Abstract: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that regulates numerous cellular processes, including metabolism, proliferation, and cell survival. Due to its multifaceted role, GSK-3 has been implicated in a variety of diseases, including Alzheimer's… read more here.
Keywords: gsk inhibitors; glycogen synthase; kinase gsk; synthase kinase ... See more keywords
Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors.
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DOI: 10.1021/acs.jmedchem.3c00364
Abstract: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that serves as an important regulator of a broad range of cellular functions. It has been linked to Alzheimer's disease as well as various other diseases, including… read more here.
Keywords: gsk inhibitors; glycogen synthase; kinase; kinase gsk ... See more keywords
Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015)
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DOI: 10.1080/13543776.2017.1259412
Abstract: ABSTRACT Introduction: Glycogen synthase kinase (GSK-3) is a serine/threonine kinase that phosphorylates more than one hundred different sequences within proteins in a variety of different pathways. It is a key component of a remarkably large… read more here.
Keywords: glycogen synthase; kinase gsk; synthase kinase; gsk inhibitors ... See more keywords