Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity
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DOI: 10.1073/pnas.1922184117
Abstract: Significance Parkinson’s disease (PD)-linked familial mutations in LRRK2 impact its enzymatic activity by commonly increasing kinase activity, either directly within the kinase domain or indirectly via the GTPase domain by impairing GTP hydrolysis. Familial LRRK2… read more here.
Keywords: kinase; g2019s lrrk2; kinase gtpase; lrrk2 ... See more keywords