Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202300855
Abstract: Photopharmacology is an emerging field that utilizes photo‐responsive molecules to enable control over the activity of a drug using light. The aim is to limit the therapeutic action of a drug at the level of… read more here.
Keywords: cancer; light activatable; kinase inhibition; tam kinase ... See more keywords
Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.08.010
Abstract: The interleukin-1 receptor-activated kinase 4 (IRAK4) belongs to the IRAK family of serine/threonine kinases and plays a central role in the innate immune response. However, the function of IRAK4 in tumor growth and progression remains… read more here.
Keywords: kinase inhibition; kinase; abc dlbcl; protein degradation ... See more keywords
Modeling Kinase Inhibition Using Highly Confident Data Sets
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00729
Abstract: Protein kinases form a consistent class of promising drug targets, and several efforts have been made to predict the activities of small molecules against a representative part of the kinome. This study continues our previous… read more here.
Keywords: kinase inhibition; modeling kinase; using highly; kinase ... See more keywords
Rho-kinase inhibition reduces subretinal fibrosis
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02709-0
Abstract: Subretinal fibrosis, a consequence of choroidal neovascularization (CNV) in age-related macular degeneration (AMD), leads to irreversible vision loss due to excessive accumulation of extracellular matrix (ECM) proteins and fibrotic scarring. Anti-VEGF therapy can reverse neovascularization,… read more here.
Keywords: fibrosis; kinase inhibition; reduces subretinal; rho kinase ... See more keywords
Glycogen synthase kinase 3β inhibition enhances Notch1 recycling
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-07-0474
Abstract: The Notch signaling pathway is essential to a variety of processes during development and throughout adulthood. It is demonstrated that GSK3β controls Notch signaling by regulating receptor recycling rates. read more here.
Keywords: kinase inhibition; glycogen synthase; inhibition enhances; synthase kinase ... See more keywords
EXTH-44. ENHANCING THERAPEUTIC APPROACHES IN HIGH-GRADE GLIOMAS: SYNERGISTIC EFFECTS OF LSD1 AND KINASE INHIBITION
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0975
Abstract: Glioblastoma (GBM) and Diffuse Intrinsic Pontine Glioma (DIPG) are devastating high-grade gliomas (HGGs) with poor prognoses. Lysine-specific demethylase 1 (LSD1) is a promising therapeutic target and a key regulator in tumor initiation and recurrence. Crosstalk… read more here.
Keywords: high grade; inhibition; kinase inhibition; lsd1 kinase ... See more keywords
Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000835
Abstract: Caspase-2 has features of both initiator and effector caspases. Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases. The… read more here.
Keywords: kinase inhibition; caspase; src kinase; hypoxia ... See more keywords
Resveratrol's Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/9012071
Abstract: Resveratrol (3,5,4′-trihydroxystilbene) is a chemical compound belonging to the group of polyphenols and flavonoids. The aim of the present study was to determine the influence of resveratrol application along with certain modulating factors, such as… read more here.
Keywords: kinase inhibition; resveratrol; rho kinase; bay k8644 ... See more keywords
Aurora Kinase A Inhibition: A Mega-Hit for Myelofibrosis Therapy?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1481
Abstract: The positive but limited efficacy of JAK inhibitors has sparked the need for alternative therapeutic targets in the treatment of myelofibrosis. The discovery of novel targets, like Aurora Kinase A, may provide new avenues of… read more here.
Keywords: therapy; aurora kinase; myelofibrosis; kinase inhibition ... See more keywords
Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-17-0177
Abstract: The receptor tyrosine kinase (RTK) MET represents a promising tumor target in a subset of glioblastomas. Most RTK inhibitors available in the clinic today, including those inhibiting MET, affect multiple targets simultaneously. Previously, it was… read more here.
Keywords: kinase inhibition; inhibition; selective met; compound ... See more keywords
Memory-like Natural Killer Cell and CD19 Antibody–Based Immunotherapy in Combination with Tyrosine Kinase Inhibition Has Antitumor Effects against Ph(-like) Acute Lymphoblastic Leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-24-0746
Abstract: The authors report combination therapy of memory-like NK cells, a CD19 leukemia epitope–directed antibody and tyrosine kinase inhibition in models of Ph-like acute lymphoblastic leukemia, to enhance immune response and improve therapeutic outcomes. read more here.
Keywords: like acute; acute lymphoblastic; lymphoblastic leukemia; kinase inhibition ... See more keywords