Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2020.08.010
Abstract: The interleukin-1 receptor-activated kinase 4 (IRAK4) belongs to the IRAK family of serine/threonine kinases and plays a central role in the innate immune response. However, the function of IRAK4 in tumor growth and progression remains… read more here.
Keywords: kinase inhibition; kinase; abc dlbcl; protein degradation ... See more keywords
Modeling Kinase Inhibition Using Highly Confident Data Sets
Sign Up to like & getrecommendations! Published in 2018 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.7b00729
Abstract: Protein kinases form a consistent class of promising drug targets, and several efforts have been made to predict the activities of small molecules against a representative part of the kinome. This study continues our previous… read more here.
Keywords: kinase inhibition; modeling kinase; using highly; kinase ... See more keywords
Glycogen synthase kinase 3β inhibition enhances Notch1 recycling
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-07-0474
Abstract: The Notch signaling pathway is essential to a variety of processes during development and throughout adulthood. It is demonstrated that GSK3β controls Notch signaling by regulating receptor recycling rates. read more here.
Keywords: kinase inhibition; glycogen synthase; inhibition enhances; synthase kinase ... See more keywords
Effects of Src kinase inhibition on expression of pro-caspase-2 after brain hypoxia in a piglet animal model
Sign Up to like & getrecommendations! Published in 2017 at "NeuroReport"
DOI: 10.1097/wnr.0000000000000835
Abstract: Caspase-2 has features of both initiator and effector caspases. Previously, we have shown that brain hypoxia-induced production of caspases 1, 3, 8, and 9 is Src kinase mediated, a nonreceptor intracellular family of kinases. The… read more here.
Keywords: kinase inhibition; caspase; src kinase; hypoxia ... See more keywords
Resveratrol's Impact on Vascular Smooth Muscle Cells Hyporeactivity: The Role of Rho-Kinase Inhibition
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/9012071
Abstract: Resveratrol (3,5,4′-trihydroxystilbene) is a chemical compound belonging to the group of polyphenols and flavonoids. The aim of the present study was to determine the influence of resveratrol application along with certain modulating factors, such as… read more here.
Keywords: kinase inhibition; resveratrol; rho kinase; bay k8644 ... See more keywords
Aurora Kinase A Inhibition: A Mega-Hit for Myelofibrosis Therapy?
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-19-1481
Abstract: The positive but limited efficacy of JAK inhibitors has sparked the need for alternative therapeutic targets in the treatment of myelofibrosis. The discovery of novel targets, like Aurora Kinase A, may provide new avenues of… read more here.
Keywords: therapy; aurora kinase; myelofibrosis; kinase inhibition ... See more keywords
Selective MET Kinase Inhibition in MET-Dependent Glioma Models Alters Gene Expression and Induces Tumor Plasticity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-17-0177
Abstract: The receptor tyrosine kinase (RTK) MET represents a promising tumor target in a subset of glioblastomas. Most RTK inhibitors available in the clinic today, including those inhibiting MET, affect multiple targets simultaneously. Previously, it was… read more here.
Keywords: kinase inhibition; inhibition; selective met; compound ... See more keywords
Solid Tumors and Kinase Inhibition: Management and Therapy Efficacy Evolution
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073830
Abstract: The increasing numbers of cancer cases worldwide and the exceedingly high mortality rates of some tumor subtypes raise the question about if the current protocols for cancer management are effective and what has been done… read more here.
Keywords: tumors kinase; therapy; kinase inhibition; management ... See more keywords
Exploring Kinase Inhibition Properties of 9H-pyrimido[5,4-b]- and [4,5-b]indol-4-amine Derivatives
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DOI: 10.3390/ph13050089
Abstract: We previously highlighted the interest in 6,5,6-fused tricyclic analogues of 4-aminoquinazolines as kinase inhibitors in the micromolar to the nanomolar range of IC50 values. For the generation of chemical libraries, the formamide-mediated cyclization of the… read more here.
Keywords: amine derivatives; kinase inhibition; pyrimido indol; indol amine ... See more keywords
Kinase Inhibition in Multiple Myeloma: Current Scenario and Clinical Perspectives
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14091784
Abstract: Multiple myeloma (MM) is a blood cell neoplasm characterized by excessive production of malignant monoclonal plasma cells (activated B lymphocytes) by the bone marrow, which end up synthesizing antibodies or antibody fragments, called M proteins,… read more here.
Keywords: inhibition multiple; myeloma; current scenario; kinase inhibition ... See more keywords