Ocular Toxicity of Mitogen-Activated Protein Kinase Inhibitors
Sign Up to like & getrecommendations! Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2016.4213
Abstract: Ocular Toxicity of Mitogen-Activated Protein Kinase Inhibitors The Oxford Eye Hospital and the Oxford Experimental Cancer Centre collaborate in monitoring patients in a number of early-phase clinical trials. In this study, we report the ocular… read more here.
Keywords: kinase inhibitors; protein kinase; mitogen activated; activated protein ... See more keywords
Adverse outcomes in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Follow‐up of patients diagnosed 2002–2017 in a complete coverage and nationwide agnostic register study
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26463
Abstract: Tyrosine kinase inhibitors (TKIs) have profoundly improved the clinical outcome for patients with chronic myeloid leukemia (CML), but their overall survival is still subnormal and the treatment is associated with adverse events. In a large… read more here.
Keywords: myeloid leukemia; chronic myeloid; kinase inhibitors; patients diagnosed ... See more keywords
The costs of treating and not treating patients with chronic myeloid leukemia with tyrosine kinase inhibitors among Medicare patients in the United States
Sign Up to like & getrecommendations! Published in 2020 at "Cancer"
DOI: 10.1002/cncr.33267
Abstract: Patients with high cost‐sharing of tyrosine kinase inhibitors (TKIs) experience delays in treatment for chronic myeloid leukemia (CML). To the authors' knowledge, the clinical outcomes among and costs for patients not receiving TKIs are not… read more here.
Keywords: kinase inhibitors; myeloid leukemia; chronic myeloid; tyrosine kinase ... See more keywords
COVID‐19 in patients with hematological malignancies: Considering the role of tyrosine kinase inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Cancer"
DOI: 10.1002/cncr.33432
Abstract: In an article previously published in Cancer, Cattaneo et al analyzed a cohort of patients with coronavirus disease 2019 (COVID-19) and hematological malignancies in March 2020, and they highlighted that subjects with chronic myeloid leukemia… read more here.
Keywords: kinase inhibitors; covid; role tyrosine; role ... See more keywords
Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology
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DOI: 10.1002/cpt.787
Abstract: Despite the fact that pharmacokinetic exposure of kinase inhibitors (KIs) is highly variable and clear relationships exist between exposure and treatment outcomes, fixed dosing is still standard practice. This review aims to summarize the available… read more here.
Keywords: kinase inhibitors; therapeutic drug; drug monitoring; oncology ... See more keywords
Genotoxicity associated with the use of tyrosine kinase inhibitors in patients with chronic myeloid leukemia
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DOI: 10.1002/em.22164
Abstract: Genotoxicity AssociatedWith the Use of Tyrosine Kinase Inhibitors in Patients With Chronic Myeloid Leukemia Pedro Aurio Maia Filho ,* Tarcı sio Paulo de Almeida Filho, Caroline de F atima Aquino Moreina-Nunes, Rommel Rodriguez Burbano, Jos… read more here.
Keywords: kinase inhibitors; inhibitors patients; use tyrosine; patients chronic ... See more keywords
Anti‐SARS‐CoV‐2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID‐19 therapy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28157
Abstract: Coronavirus disease 2019 (COVID‐19) remains a major public health concern, and vaccine unavailability, hesitancy, or failure underscore the need for discovery of efficacious antiviral drug therapies. Numerous approved drugs target protein kinases associated with viral… read more here.
Keywords: kinase inhibitors; infection; kinase; activity ... See more keywords
Gilteritinib: Repurposing of AXL‐targeting kinase inhibitors against COVID‐19
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28592
Abstract: The coronavirus disease‐19 (COVID‐19) is an ongoing infection outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), a novel positive single‐stranded, enveloped RNA virus belonging to the genus Betacoronavirus. During the pandemic, the SARS‐CoV‐2… read more here.
Keywords: kinase inhibitors; axl targeting; repurposing axl; targeting kinase ... See more keywords
Synthesis of histidine kinase inhibitors and their biological properties
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DOI: 10.1002/med.21651
Abstract: Infections caused by multidrug‐resistant bacteria represent a significant and ever‐increasing cause of morbidity and mortality. There is thus an urgent need to develop efficient and well‐tolerated antibacterials targeting unique cellular processes. Numerous studies have led… read more here.
Keywords: kinase inhibitors; histidine kinase; inhibitors biological; kinase ... See more keywords
Differentiating pulmonary hypertension associated with protein kinase inhibitors
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DOI: 10.1002/pul2.12075
Abstract: Abstract Protein kinase inhibitors (PKIs) have been implicated in pulmonary vascular toxicities including risk factors for at least three of the five World Health Organization groups of pulmonary hypertension (PH). These toxicities include direct drug‐induced… read more here.
Keywords: protein kinase; pulmonary hypertension; differentiating pulmonary; kinase inhibitors ... See more keywords
Mapping Biological Activities to Different Types of Molecular Scaffolds: Exemplary Application to Protein Kinase Inhibitors.
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DOI: 10.1007/978-1-4939-8639-2_10
Abstract: Scaffolds were originally introduced to delineate core structures of active compounds. They are also used to assess the ability of computational methods to identify structurally diverse active compounds. Biological activities of compound series are often… read more here.
Keywords: kinase inhibitors; scaffolds exemplary; exemplary application; biological activities ... See more keywords