Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano‐polyplexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.04.045
Abstract: ABSTRACT Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide‐polymer nano‐polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously‐described platform technology for intracellular peptide delivery and are formulated… read more here.
Keywords: post lyophilization; nps lyophilized; kinase inhibitory; lyophilization ... See more keywords
Raf Kinase Inhibitory Protein regulates the cAMP-dependent protein kinase signaling pathway through a positive feedback loop
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121867119
Abstract: Significance Cancer and heart disease are among the most progressive causes of mortality today. Two major regulators of these disease states are the MAP kinase and PKA signaling pathways. Ensuring proper signaling of these pathways… read more here.
Keywords: raf kinase; kinase inhibitory; kinase; positive feedback ... See more keywords
Suramin Targets the Conserved Ligand-Binding Pocket of Human Raf1 Kinase Inhibitory Protein
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DOI: 10.3390/molecules26041151
Abstract: Suramin was initially used to treat African sleeping sickness and has been clinically tested to treat human cancers and HIV infection in the recent years. However, the therapeutic index is low with numerous clinical side-effects,… read more here.
Keywords: protein; inhibitory protein; conserved ligand; kinase inhibitory ... See more keywords
Clinical and prognostic significance of Raf kinase inhibitory protein expression in gastrointestinal stromal tumors
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DOI: 10.3748/wjg.v24.i23.2508
Abstract: AIM To detect the expression of Raf kinase inhibitory protein (RKIP) in gastrointestinal stromal tumors (GISTs) and to analyze its relationship with clinicopatholgical characteristics and prognosis of this disease. METHODS Sixty-three patients with pathologically diagnosed… read more here.
Keywords: prognosis; raf kinase; kinase inhibitory; expression ... See more keywords