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Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00036
Abstract: The feedback activation of the Janus kinase (JAK)-STAT pathway leads to the fact that solid cancers are not sensitive to histone deacetylase (HDAC) inhibitors. Herein, a series of novel 2-amino-4-phenylaminopyrimidine JAK/HDAC dual-target inhibitors based on…
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Keywords:
malignancies solid;
kinase jak;
hdac;
solid cancers ... See more keywords
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Published in 2023 at "Expert opinion on drug safety"
DOI: 10.1080/14740338.2023.2181339
Abstract: BACKGROUND Recently, there have been clinical reports of hepatitis B virus reactivation (HBVr) related with Janus kinase (JAK) inhibitors. However, there were no studies to investigate the association between HBVr and different JAK inhibitors. RESEARCH…
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Keywords:
jak inhibitors;
kinase jak;
jak;
virus reactivation ... See more keywords
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Published in 2021 at "BMC Research Notes"
DOI: 10.1186/s13104-021-05860-w
Abstract: Objective Interferon-gamma (IFN-γ) is overexpressed in rheumatoid synovium and thought to be involved in the pathogenesis of rheumatoid arthritis (RA). In this study, we examined our hypothesis that IFN-γ activates innate immune cells and upregulates…
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Keywords:
kinase jak;
ifn;
signal transducer;
phosphorylation ... See more keywords