Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2020.104948
Abstract: Mutations in leucine-rich repeat kinase 2 (LRRK2) are an established cause of inherited Parkinson's disease (PD). LRRK2 is expressed in both neurons and glia in the central nervous system, but its physiological function(s) in each… read more here.
Keywords: clathrin mediated; kinase lrrk2; disease; parkinson disease ... See more keywords
A Leucine-Rich Repeat Kinase 2 (LRRK2) Pathway Biomarker Characterization Study in Patients with Parkinson's Disease with and without LRRK2 Mutations and Healthy Controls.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical and translational science"
DOI: 10.1111/cts.13541
Abstract: Increased leucine-rich repeat kinase 2 (LRRK2) kinase activity is an established risk factor for Parkinson's disease (PD), and several LRRK2-kinase inhibitors are in clinical development as potential novel disease modifying therapeutics. This biomarker characterization study… read more here.
Keywords: repeat kinase; leucine rich; kinase; rich repeat ... See more keywords