Reduction of advanced tau-mediated memory deficits by the MAP kinase p38γ
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DOI: 10.1007/s00401-020-02191-1
Abstract: Hyperphosphorylation of the neuronal tau protein contributes to Alzheimer’s disease (AD) by promoting tau pathology and neuronal and cognitive deficits. In contrast, we have previously shown that site-specific tau phosphorylation can inhibit toxic signals induced… read more here.
Keywords: kinase p38; tau; memory deficits; map kinase ... See more keywords
Direct monitoring of the conformational equilibria of the activation loop in the mitogen-activated protein kinase p38α.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc06128a
Abstract: Conformational transitions in protein kinases are crucial for the biological function of these enzymes. Here, we characterize and assess conformational equilibria of the activation loop and the effect of small molecule inhibitors in the MAP… read more here.
Keywords: equilibria activation; kinase p38; conformational equilibria; activation loop ... See more keywords