Label‐Free Fluorescent Kinase and Phosphatase Enzyme Assays with Supramolecular Host‐Dye Pairs
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DOI: 10.1002/open.201900299
Abstract: Abstract The combination of the macrocyclic hosts p‐sulfonatocalix[4]arene and cucurbit[7]uril with the fluorescent dyes lucigenin and berberine affords two label‐free enzyme assays for the detection of kinase and phosphatase activity by fluorescence monitoring. In contrast… read more here.
Keywords: kinase phosphatase; label free; enzyme assays;
Focus on Mitogen-Activated Kinase Phosphatase-1: Looking for the Roots of Depression in the Anterior Cingulate Cortex
Sign Up to like & getrecommendations! Published in 2017 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2017.06.027
Abstract: Understanding the molecular and neuroanatomical underpinnings of mood disorders such as depression and anxiety may help to develop diagnostic tools or to identify alternative targets for drug discovery. Mood disorders share comorbidities with pain syndromes.… read more here.
Keywords: depression; kinase phosphatase; mood disorders; mood ... See more keywords
Polynucleotide kinase-phosphatase (PNKP) mutations and neurologic disease
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DOI: 10.1016/j.mad.2016.04.009
Abstract: A variety of human neurologic diseases are caused by inherited defects in DNA repair. In many cases, these syndromes almost exclusively impact the nervous system, underscoring the critical requirement for genome stability in this tissue.… read more here.
Keywords: kinase phosphatase; pnkp; polynucleotide kinase; pnkp mutations ... See more keywords
Overexpression of Mitogen-activated protein kinase phosphatase-3 (MKP-3) reduces FoxO1 phosphorylation in mice hypothalamus
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DOI: 10.1016/j.neulet.2017.08.067
Abstract: The mitogen-activated kinase phosphatase-3 (MKP-3) has gained great importance in the scientific community by acting as a regulator of the cell cycle through dephosphorylation of FoxO1, an important transcription factor involved in the insulin intracellular… read more here.
Keywords: mkp; kinase phosphatase; hypothalamus; foxo1 phosphorylation ... See more keywords
The Importance of Kinase-Phosphatase Integration: Lessons from Mitosis.
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DOI: 10.1016/j.tcb.2017.09.005
Abstract: Kinases and phosphatases work antagonistically to control the behaviour of individual substrate molecules. This can be incorrectly extrapolated to imply that they also work antagonistically on the signals or processes that these molecules control. In… read more here.
Keywords: importance kinase; mitosis; phosphatase integration; kinase phosphatase ... See more keywords