Kinase Photoaffinity Labeling Reveals Low Selectivity Profile of the IRE1 Targeting Imidazopyrazine-Based KIRA6 Inhibitor.
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DOI: 10.1021/acschembio.0c00802
Abstract: Inositol-requiring enzyme 1α (IRE1α) is one of three endoplasmic reticulum stress sensors. Upon activation of its kinase domain, IRE1α splices the mRNA substrate XBP1, which activates the unfolded protein response. IRE1α has emerged as a… read more here.
Keywords: inhibitor; kinase; based kira6; kinase photoaffinity ... See more keywords