Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111718
Abstract: Phosphatidylinositol-3 kinase (PI3K) pathway is one of the most frequently activated pathogenic signaling cascades in human malignancies. PI3K is genetically mutated or overexpressed in a wide variety of cancers including ovarian, breast, prostate, gastric, colorectal,… read more here.
Keywords: pi3k; kinase pi3k; selective pi3k; phosphatidylinositol kinase ... See more keywords
Phosphoinositide 3-kinase δ (PI3Kδ) in respiratory disease.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical Society transactions"
DOI: 10.1042/bst20170467
Abstract: Defining features of chronic airway diseases include abnormal and persistent inflammatory processes, impaired airway epithelial integrity and function, and increased susceptibility to recurrent respiratory infections. Phosphoinositide 3-kinases (PI3K) are lipid kinases, which contribute to multiple… read more here.
Keywords: pi3k; kinase pi3k; respiratory disease; pi3k respiratory ... See more keywords
Association of phosphatidylinositol 3-kinase (PI3K) pathway activation with increased immune checkpoint expression in colorectal cancer (CRC) patients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.4_suppl.653
Abstract: 653Background: PI3K pathway is a known modulator of anti-tumor immune response and is frequently activated in CRC through genetic alterations such as PTEN loss (PTENloss) and PIK3CA mutations (PIK3... read more here.
Keywords: pathway activation; kinase pi3k; association phosphatidylinositol; activation increased ... See more keywords
Phosphoinositide 3-Kinase (PI3K) Inhibitors and Breast Cancer: An Overview of Current Achievements
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15051416
Abstract: Simple Summary Breast cancer remains the fourth-leading cause of death worldwide, and therapeutic improvement is warranted. The phosphatidylinositol 3-kinase (PI3K) pathway is one of the major pathways in oncogenesis, and PI3K alterations are common in… read more here.
Keywords: pi3k inhibitors; breast cancer; cancer; kinase pi3k ... See more keywords