Disseminated Mycoplasma Orale Infection in Patients With Phosphoinositide-3-Kinase Regulatory Subunit 1 Mutations.
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DOI: 10.1093/ofid/ofac472
Abstract: Mycoplasma orale is a rare cause of invasive infection in immunodeficient hosts. Phosphatidylinositol 3-kinase, regulatory subunit 1 (PI3KR1) mutations predispose patients to sinopulmonary infections, alongside bronchiectasis autoimmunity and lymphoproliferation. We report 2 cases of PI3KR1… read more here.
Keywords: infection; kinase regulatory; disseminated mycoplasma; regulatory subunit ... See more keywords
Phosphoinositide 3‐kinase δ is a regulatory T‐cell target in cancer immunotherapy
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DOI: 10.1111/imm.13082
Abstract: Tumour infiltration by regulatory T (Treg) cells contributes to suppression of the anti‐tumour immune response, which limits the efficacy of immune‐mediated cancer therapies. The phosphoinositide 3‐kinase (PI3K) pathway has key roles in mediating the function… read more here.
Keywords: regulatory cell; kinase regulatory; phosphoinositide kinase; cell target ... See more keywords
Proteome and Phosphoproteome Analyses Reveal the Kinase Regulatory Network Involved in Glycogen Synthesis Kinase 3β
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DOI: 10.3389/fgene.2021.657140
Abstract: Diabetic nephropathy is the most common chronic kidney disease in the world and the main cause of end-stage renal disease (ESRD). The structural integrity of podocytes is fundamental to the normal function of the glomerulus,… read more here.
Keywords: protein; regulatory network; network; analysis ... See more keywords