Control of phosphatidylinositol‐3‐kinase signaling by nanoscale membrane compartmentalization
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DOI: 10.1002/bies.202200196
Abstract: Phosphatidylinositol‐3‐kinases (PI3Ks) are lipid kinases that produce 3‐phosphorylated derivatives of phosphatidylinositol upon activation by various cues. These 3‐phosphorylated lipids bind to various protein effectors to control many cellular functions. Lipid phosphatases such as phosphatase and… read more here.
Keywords: control phosphatidylinositol; phosphatidylinositol kinase; nanoscale membrane; membrane ... See more keywords
Lowering Sample Requirements to Study Tyrosine Kinase Signaling Using Phosphoproteomics with the TMT Calibrator Approach
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DOI: 10.1002/pmic.202000116
Abstract: Analysis of tyrosine kinase signaling is critical for the development of targeted cancer therapy. Currently, immunoprecipitation of phosphotyrosine (pY) peptides prior to liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) is used to profile tyrosine kinase substrates. A… read more here.
Keywords: sample; kinase signaling; sample requirements; calibrator ... See more keywords
PI 3-Kinase Signaling: AKTing up inside the Cell.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.09.006
Abstract: In this issue of Molecular Cell, Liu et al. (2018) show that PI34P2 and PIP3, the lipid products of class I phosphoinositide 3-kinase (PI3K), display distinct spatiotemporal kinetics in cells that result in differential activation of… read more here.
Keywords: cell kinase; kinase; akting inside; kinase signaling ... See more keywords
Proteomic sensors for quantitative multiplexed and spatial monitoring of kinase signaling
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DOI: 10.1038/s41467-025-65950-2
Abstract: Understanding kinase action requires precise quantitative measurements of their activity in vivo. In addition, the ability to capture spatial information of kinase activity is crucial to deconvolute complex signaling networks, interrogate multifaceted kinase actions, and… read more here.
Keywords: multiplexed spatial; kinase action; prokas; kinase signaling ... See more keywords
Protein kinase C δ signaling is required for dietary prebiotic-induced strengthening of intestinal epithelial barrier function
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DOI: 10.1038/srep40820
Abstract: Prebiotics are non-digestible oligosaccharides that promote the growth of beneficial gut microbes, but it is unclear whether they also have direct effects on the intestinal mucosal barrier. Here we demonstrate two commercial prebiotics, inulin and… read more here.
Keywords: required dietary; barrier; dietary prebiotic; signaling required ... See more keywords
Recent studies on protein kinase signaling inhibitors based on thiazoles: review to date
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DOI: 10.1039/d4ra05601a
Abstract: Due to the important role of protein kinases in protein phosphorylation within vital cellular processes, their abnormal function, especially in cancer situations, has underscored their importance in therapy. Thiazole structures are versatile frameworks present in… read more here.
Keywords: protein kinase; studies protein; kinase signaling; inhibitors based ... See more keywords
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq8437
Abstract: Dysregulation of kinase signaling pathways favors tumor cell survival and therapy resistance in cancer. Here, we reveal a posttranslational regulation of kinase signaling and nuclear receptor activity via deubiquitination in T cell acute lymphoblastic leukemia… read more here.
Keywords: deubiquitination; kinase; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Antitumorigenic Effects of Inhibiting Ephrin Receptor Kinase Signaling by GLPG1790 against Colorectal Cancer Cell Lines In Vitro and In Vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oncology"
DOI: 10.1155/2020/9342732
Abstract: Erythropoietin-producing hepatocellular receptors (Eph) promote the onset and sustain the progression of cancers such as colorectal cancer (CRC), in which the A2 subtype of Eph receptor expression has been shown to correlate with a poor… read more here.
Keywords: vitro vivo; cell lines; colorectal cancer; kinase signaling ... See more keywords
Abstract 3168: Pancreatic cancer lipid theft is mediated by MAP Kinase signaling in adipocytes
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DOI: 10.1158/1538-7445.am2021-3168
Abstract: Obesity is a major risk factor which drives cancer progression in a variety of cancers, including pancreatic ductal adenocarcinoma (PDAC). In obese individuals the adipose tissue becomes reactive, therefore the crosstalk between adipose tissue and… read more here.
Keywords: cancer cells; signaling adipocytes; cancer; map kinase ... See more keywords
Abstract 525: A comprehensive approach: Copper chelation therapy modulates epigenetic, kinase signaling and metabolic pathways in diffuse midline gliomas (DMG)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-525
Abstract: Diffuse Midline Gliomas (DMG) are incurable pediatric brain tumors driven by histone mutation H3K27M, globally reducing H3K27 trimethylation altering the epigenome and deregulating gene expression. These mutations often partner with and are strongly integrated into… read more here.
Keywords: dmg; epigenetic kinase; copper; kinase signaling ... See more keywords
Angiotensin II Silencing Alleviates Erectile Dysfunction Through Down-Regulating the Rhoa/Rho Kinase Signaling Pathway in Rats with Diabetes Mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000486919
Abstract: Background/Aims: We aim to explore the role of angiotensin (Ang)II and the RhoA/Rho kinase signaling pathway in the pathogenesis of erectile dysfunction in diabetes mellitus (DM). Methods: Male Sprague-Dawley (SD) rats were used for experiments… read more here.
Keywords: kinase; erectile dysfunction; signaling pathway; kinase signaling ... See more keywords