Binding mechanism of adenylate kinase‐specific monobodies
Sign Up to like & getrecommendations! Published in 2025 at "FEBS Letters"
DOI: 10.1002/1873-3468.70076
Abstract: Monobodies are synthetic antibody‐mimetic proteins that regulate enzyme functions through protein–protein interactions. In this study, we investigated the binding mechanisms of monobodies to adenylate kinase (Adk). Calorimetric and X‐ray crystallographic analyses revealed that CL‐1, a… read more here.
Keywords: adenylate kinase; specific monobodies; kinase specific; mechanism adenylate ... See more keywords
Phosformer: an explainable transformer model for protein kinase-specific phosphorylation predictions
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad046
Abstract: Abstract Motivation The human genome encodes over 500 distinct protein kinases which regulate nearly all cellular processes by the specific phosphorylation of protein substrates. While advances in mass spectrometry and proteomics studies have identified thousands… read more here.
Keywords: kinase specific; kinase; specific phosphorylation; model ... See more keywords