Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9709-6
Abstract: Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer development and progression. MARCKS is tethered to the plasma membrane but can shuttle… read more here.
Keywords: kinase substrate; alanine rich; myristoylated alanine; substrate marcks ... See more keywords
Deciphering the dark cancer phosphoproteome using machine-learned co-regulation of phosphosites
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DOI: 10.1038/s41467-025-57993-2
Abstract: Mass spectrometry-based phosphoproteomics offers a comprehensive view of protein phosphorylation, yet our limited knowledge about the regulation and function of most phosphosites hampers the extraction of meaningful biological insights. To address this challenge, we integrate… read more here.
Keywords: cancer; kinase substrate; machine learning; deciphering dark ... See more keywords
Using explainable machine learning to uncover the kinase–substrate interaction landscape
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DOI: 10.1093/bioinformatics/btae033
Abstract: Abstract Motivation Phosphorylation, a post-translational modification regulated by protein kinase enzymes, plays an essential role in almost all cellular processes. Understanding how each of the nearly 500 human protein kinases selectively phosphorylates their substrates is… read more here.
Keywords: kinase substrate; machine learning; model; kinase ... See more keywords
How long should a kiss last between a kinase and its substrate?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13240
Abstract: To the editor - The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood. We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic… read more here.
Keywords: kiss last; kinase; long kiss; kinase substrate ... See more keywords
Abstract 1810: Dysregulation of myristoylated alanine-rich C kinase substrate (MARCKS): A novel therapeutic target in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1810
Abstract: Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/VEGF signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale… read more here.
Keywords: kinase substrate; renal cell; kinase; target ... See more keywords
Abstract 3360: Myristoylated alanine-rich C-kinase substrate (MARCKS) as a target for pathological tunneling nanotubes in glioblastoma
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-3360
Abstract: Background: Glioblastoma (GBM) is a lethal brain malignancy with a median survival of read more here.
Keywords: alanine rich; kinase substrate; med2; rich kinase ... See more keywords
Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies
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DOI: 10.1186/s40364-021-00286-9
Abstract: The myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been at the crossroads of multiple signaling pathways that govern several critical operations in normal and malignant cellular physiology. Functioning as a target of protein kinase C,… read more here.
Keywords: kinase substrate; alanine rich; myristoylated alanine; kinase ... See more keywords
Identification of the Kinase-Substrate Recognition Interface between MYPT1 and Rho-Kinase
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12020159
Abstract: Protein kinases exert physiological functions through phosphorylating their specific substrates; however, the mode of kinase–substrate recognition is not fully understood. Rho-kinase is a Ser/Thr protein kinase that regulates cytoskeletal reorganization through phosphorylating myosin light chain… read more here.
Keywords: kinase; kinase substrate; rho kinase; substrate recognition ... See more keywords