Myristoylated alanine-rich C kinase substrate (MARCKS): a multirole signaling protein in cancers
Sign Up to like & getrecommendations! Published in 2017 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-017-9709-6
Abstract: Emerging evidence implicates myristoylated alanine-rich C-kinase substrate (MARCKS), a major substrate of protein kinase C (PKC), in a critical role for cancer development and progression. MARCKS is tethered to the plasma membrane but can shuttle… read more here.
Keywords: kinase substrate; alanine rich; myristoylated alanine; substrate marcks ... See more keywords
How long should a kiss last between a kinase and its substrate?
Sign Up to like & getrecommendations! Published in 2022 at "Journal of integrative plant biology"
DOI: 10.1111/jipb.13240
Abstract: To the editor - The molecular mechanisms underlying the trade-off between plant growth and responses to the ever-changing environment are poorly understood. We previously revealed a phosphorylation-based regulatory loop between the plant stress hormone abscisic… read more here.
Keywords: kiss last; kinase; long kiss; kinase substrate ... See more keywords
Abstract 1810: Dysregulation of myristoylated alanine-rich C kinase substrate (MARCKS): A novel therapeutic target in renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-1810
Abstract: Targeted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/VEGF signaling, are initially effective against kidney cancer (or renal cell carcinoma, RCC); however, drug resistance frequently occurs via subsequent activation of alternative pathways. Through genome-scale… read more here.
Keywords: kinase substrate; renal cell; kinase; target ... See more keywords
Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies
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DOI: 10.1186/s40364-021-00286-9
Abstract: The myristoylated alanine-rich C-kinase substrate (MARCKS) protein has been at the crossroads of multiple signaling pathways that govern several critical operations in normal and malignant cellular physiology. Functioning as a target of protein kinase C,… read more here.
Keywords: kinase substrate; alanine rich; myristoylated alanine; kinase ... See more keywords
Identification of the Kinase-Substrate Recognition Interface between MYPT1 and Rho-Kinase
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DOI: 10.3390/biom12020159
Abstract: Protein kinases exert physiological functions through phosphorylating their specific substrates; however, the mode of kinase–substrate recognition is not fully understood. Rho-kinase is a Ser/Thr protein kinase that regulates cytoskeletal reorganization through phosphorylating myosin light chain… read more here.
Keywords: kinase; kinase substrate; rho kinase; substrate recognition ... See more keywords