Recent advances in understanding spleen tyrosine kinase (SYK) in human biology and disease, with a focus on fostamatinib.
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DOI: 10.1080/09537104.2022.2131751
Abstract: Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target… read more here.
Keywords: kinase syk; biology; tyrosine kinase; spleen tyrosine ... See more keywords
STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk
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DOI: 10.1128/mbio.03228-21
Abstract: The innate immune response to virus infection leads to interferon production and inhibition of viral replication. STING, an ER-bound protein, mediates such a response to cytoplasmic cellular or microbial DNA. ABSTRACT The nature and the… read more here.
Keywords: response; tyrosine kinase; induction; virus ... See more keywords