Ciliogenesis associated kinase 1: targets and functions in various organ systems
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13600
Abstract: Ciliogenesis associated kinase 1 (CILK1) was previously known as intestinal cell kinase because it was cloned from that origin. However, CILK1 is now recognized as a widely expressed and highly conserved serine/threonine protein kinase. Mutations… read more here.
Keywords: ciliogenesis associated; associated kinase; cilk1; kinase targets ... See more keywords
Inverse screening of Simvastatin kinase targets from glioblastoma druggable kinome
Sign Up to like & getrecommendations! Published in 2020 at "Computational biology and chemistry"
DOI: 10.1016/j.compbiolchem.2020.107243
Abstract: The statin drug Simvastatin is a HMG-CoA reductase inhibitor that has been widely used to lower blood lipid. However, the drug is clinically observed to reposition a significant suppressing potency on glioblastoma (GBM) by unexpectedly… read more here.
Keywords: inverse screening; simvastatin; kinase; druggable kinome ... See more keywords
Identification of Kinase Targets for Enhancing the Antitumor Activity of Eribulin in Triple-Negative Breast Cell Lines
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DOI: 10.3390/biomedicines11030735
Abstract: Background: Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype of breast cancer, and current treatments are only partially effective in disease control. More effective combination approaches are needed to improve the survival of… read more here.
Keywords: breast; triple negative; inhibitor; kinase targets ... See more keywords
Novel Tyrosine Kinase Targets in Urothelial Carcinoma
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DOI: 10.3390/ijms22020747
Abstract: Urothelial carcinoma represents one of the most prevalent types of cancer worldwide, and its incidence is expected to grow. Although the treatment of the advanced disease was based on chemotherapy for decades, the developments of… read more here.
Keywords: carcinoma; novel tyrosine; kinase targets; urothelial carcinoma ... See more keywords