Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2).
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DOI: 10.1021/acs.biochem.2c00451
Abstract: Pyrimidine nucleotide biosynthesis in humans is a promising chemotherapeutic target for infectious diseases caused by RNA viruses. Because mammalian cells derive pyrimidine ribonucleotides through a combination of de novo biosynthesis and salvage, combined inhibition of… read more here.
Keywords: inhibitors human; kinase uck2; cytidine kinase; uridine cytidine ... See more keywords