Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription.
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2021.02.002
Abstract: Phosphorylation of RNA polymerase II (RNAP II) coordinates the temporal progression of eukaryotic transcription. The development and application of chemical genetic methods have enhanced our ability to investigate the intricate and intertwined pathways regulated by… read more here.
Keywords: kinases phosphatases; transcription; chemical biology; rna polymerase ... See more keywords
Methods and approaches to disease mechanisms using systems kinomics
Sign Up to like & getrecommendations! Published in 2018 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2017.12.004
Abstract: All cellular functions, ranging from regular cell maintenance and homeostasis, specialized functions specific to cellular types, or generating responses due to external stimulus, are mediated by proteins within the cell. Regulation of these proteins allows… read more here.
Keywords: protein; kinases phosphatases; disease mechanisms; approaches disease ... See more keywords
Phosphoregulation of the autophagy machinery by kinases and phosphatases.
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DOI: 10.1080/15548627.2021.1909407
Abstract: Eukaryotic cells use post-translational modifications to diversify and dynamically coordinate the function and properties of protein networks within various cellular processes. For example, the process of autophagy strongly depends on the balanced action of kinases… read more here.
Keywords: kinases phosphatases; phosphoregulation autophagy; autophagy machinery;
New connections: Kinases and phosphatases in control of mitosis
Sign Up to like & getrecommendations! Published in 2018 at "Science Signaling"
DOI: 10.1126/scisignal.aau0696
Abstract: Two studies in this week’s issue of Science Signaling reveal coordinated regulation of kinases and phosphatases during cell cycle progression. Two studies in this week’s issue of Science Signaling reveal coordinated regulation of kinases and… read more here.
Keywords: kinases phosphatases; science signaling; phosphatases control; new connections ... See more keywords
A direct fluorometric activity assay for lipid kinases and phosphatases.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of lipid research"
DOI: 10.1194/jlr.d120000794
Abstract: Lipid kinases and phosphatases play key roles in cell signaling and regulation, are implicated in many human diseases, and are thus attractive targets for drug development. Currently, no direct in vitro activity assay is available… read more here.
Keywords: kinases phosphatases; direct fluorometric; fluorometric activity; activity assay ... See more keywords
Systematic inference of indirect transcriptional regulation by protein kinases and phosphatases
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009414
Abstract: Gene expression is controlled by pathways of regulatory factors often involving the activity of protein kinases on transcription factor proteins. Despite this well established mechanism, the number of well described pathways that include the regulatory… read more here.
Keywords: protein kinases; transcription; kinases phosphatases; regulation ... See more keywords