Metal coordination in kinases and pseudokinases.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Society transactions"
DOI: 10.1042/bst20160327
Abstract: Protein phosphorylation, mediated by protein kinases, is a key event in the regulation of eukaryotic signal transduction. The majority of eukaryotic protein kinases perform phosphoryl transfer, assisted by two divalent metal ions. About 10% of… read more here.
Keywords: protein; kinases pseudokinases; coordination kinases; protein kinases ... See more keywords
Recent advances in targeting protein kinases and pseudokinases in cancer biology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.942500
Abstract: Kinases still remain the most favorable members of the druggable genome, and there are an increasing number of kinase inhibitors approved by the FDA to treat a variety of cancers. Here, we summarize recent developments… read more here.
Keywords: kinases pseudokinases; advances targeting; biology; recent advances ... See more keywords