Vitamin D enhances antiepileptic and cognitive effects of lamotrigine in pentylenetetrazole-kindled rats
Sign Up to like & getrecommendations! Published in 2017 at "Brain Research"
DOI: 10.1016/j.brainres.2017.08.011
Abstract: Despite long use of antiepileptic drugs, it remains a challenge to achieve seizure control while reducing adverse effects and preventing cognitive impairment. Several lines of evidence suggest a role of vitamin D in epilepsy. So… read more here.
Keywords: enhances antiepileptic; vitamin enhances; vitamin lamotrigine; kindled rats ... See more keywords
The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats
Sign Up to like & getrecommendations! Published in 2022 at "Neurological Research"
DOI: 10.1080/01616412.2022.2064700
Abstract: ABSTRACT Objectives Recently, studies have demonstrated that serotonin type 7 receptors (5-HT7) have conflincting effects on neuronal excitability in different brain regions. However, the effect of 5-HT7 on seizures has not been exactly elucidated yet.… read more here.
Keywords: ptz; antagonist 269970; seizure; ht7 receptor ... See more keywords
Docosahexaenoic acid prevents resistance to antiepileptic drugs in two animal models of drug-resistant epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Nutritional Neuroscience"
DOI: 10.1080/1028415x.2017.1422903
Abstract: Objectives: One-third of epileptic patients are resistant to antiepileptic drugs. Few clinical studies with small sample size indicate that polyunsaturated fatty acids could control drug-resistant epilepsy. We examined the efficacy of acute and chronic administration… read more here.
Keywords: ltg; kindled rats; drug resistant; dha ... See more keywords
Progressive Neuronal Loss in Epilepsy – A Long-Standing Conundrum Finally Resolved?
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DOI: 10.1177/15357597211030385
Abstract: Purpose: It remains controversial whether neuronal damage and synaptic reorganization found in some forms of epilepsy are the result of an initial injury and potentially contributory to the epileptic condition or are the cumulative effect… read more here.
Keywords: seizure; progressive neuronal; epilepsy; kindled rats ... See more keywords
Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0224834
Abstract: Background The precise effect of low frequency stimulation (LFS) as a newly postulated, anticonvulsant therapeutic approach on seizure-induced changes in synaptic transmission has not been completely determined. Hypothesis In this study, the LFS effect on… read more here.
Keywords: synaptic transmission; kindled animals; gene expression; kindled rats ... See more keywords