Kindlin‐3 maintains marginal zone B cells but confines follicular B cell activation and differentiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1hi0621-313r
Abstract: Integrin‐mediated interactions between hematopoietic cells and their microenvironment are important for the development and function of immune cells. Here, the role of the integrin adaptor Kindlin‐3 in B cell homeostasis is studied. Comparing the individual… read more here.
Keywords: kindlin; follicular cell; cell; marginal zone ... See more keywords
Kindlin-2–miR-1258–TCF4 feedback loop promotes hepatocellular carcinoma invasion and metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-022-01866-8
Abstract: Upregulated Kindlin-2 expression in hepatocellular carcinoma (HCC) correlates with metastasis and poor prognosis. In this study, we investigated the molecular mechanism of Kindlin-2 in HCC. Kindlin-2 downstream pathways were explored through microRNA sequencing. The Kindlin-2–miR-1258–TCF4… read more here.
Keywords: expression; mir 1258; kindlin mir; kindlin ... See more keywords
Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice
Sign Up to like & getrecommendations! Published in 2018 at "Science China Life Sciences"
DOI: 10.1007/s11427-018-9336-6
Abstract: Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using… read more here.
Keywords: integrin interacting; transgenic mice; mammary gland; interacting protein ... See more keywords
The Kindlin Outside Connection.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.10.010
Abstract: Transmembrane integrin bridges the extracellular and intracellular environments and is activated by focal adhesion proteins, talin and kindlin. Activated integrin engages ligands from the extracellular matrix and controls intracellular responses. In this issue of Structure,… read more here.
Keywords: outside connection; kindlin outside; kindlin;
Mechanotransduction: Kindlin' the fate of mesenchymal stem cells
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2018.21
Abstract: Kindlin-2 controls mesenchymal stem cell differentiation in response to matrix stiffness by regulating the levels and activity of YAP and TAZ. read more here.
Keywords: mechanotransduction kindlin; fate mesenchymal; mesenchymal stem; kindlin fate ... See more keywords
Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00328-y
Abstract: In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that deleting Kindlin-2 in osteoblastic cells… read more here.
Keywords: homeostasis; regulates skeletal; bone; kindlin regulates ... See more keywords
Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.07.13.499909
Abstract: Inflammatory liver diseases are a major cause of morbidity and mortality worldwide; however, underlying mechanisms are incompletely understood. Here we show that deleting the focal adhesion protein Kindlin-2 in hepatocytes using the Alb-Cre transgenic mice… read more here.
Keywords: kindlin inhibits; function; liver; kindlin loss ... See more keywords
Involvement of kindlin‐2 in irisin’s protection against ischaemia reperfusion‐induced liver injury in high‐fat diet‐fed mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.15910
Abstract: Liver steatosis is associated with increased ischaemia reperfusion (I/R) injury. Our previous studies have shown that irisin, an exercise‐induced hormone, mitigates I/R injury via binding to αVβ5 integrin. However, the effect of irisin on I/R… read more here.
Keywords: reperfusion; irisin; mice; liver injury ... See more keywords
NDR1-Dependent Regulation of Kindlin-3 Controls High-Affinity LFA-1 Binding and Immune Synapse Organization
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00424-16
Abstract: ABSTRACT Antigen-specific adhesion between T cells and antigen-presenting cells (APC) during the formation of the immunological synapse (IS) is mediated by LFA-1 and ICAM-1. Here, LFA-1–ICAM-1 interactions were measured at the single-molecule level on supported… read more here.
Keywords: synapse; high affinity; affinity lfa; organization ... See more keywords
Kindlin-2 Regulates the Growth of Breast Cancer Tumors by Activating CSF-1-Mediated Macrophage Infiltration.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-2337
Abstract: Interplay between tumor cells and host cells in the tumor microenvironment dictates the development of all cancers. In breast cancer, malignant cells educate host macrophages to adopt a protumorigenic phenotype. In this study, we show… read more here.
Keywords: csf; breast cancer; macrophage; cancer ... See more keywords
Kindlin-3 recruitment to the plasma membrane precedes high affinity β2 integrin and neutrophil arrest from rolling.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2019003446
Abstract: Integrin-mediated neutrophil adhesion starts by arrest from rolling. Activation of integrins involves conformational changes from an inactive bent conformation to an extended conformation (E+) with high affinity for ligand binding (H+). The cytoplasmic protein kindlin-3… read more here.
Keywords: affinity integrin; high affinity; plasma membrane; kindlin ... See more keywords