Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00328-y
Abstract: In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that deleting Kindlin-2 in osteoblastic cells… read more here.
Keywords: homeostasis; regulates skeletal; bone; kindlin regulates ... See more keywords
Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-019-14186-y
Abstract: β-Cell dysfunction and reduction in β-cell mass are hallmark events of diabetes mellitus. Here we show that β-cells express abundant Kindlin-2 and deleting its expression causes severe diabetes-like phenotypes without markedly causing peripheral insulin resistance.… read more here.
Keywords: cell; expression; mass; kindlin loss ... See more keywords
Kindlin-2 inhibits TNF/NF-κB-Caspase 8 pathway in hepatocytes to maintain liver development and function
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.07.13.499909
Abstract: Inflammatory liver diseases are a major cause of morbidity and mortality worldwide; however, underlying mechanisms are incompletely understood. Here we show that deleting the focal adhesion protein Kindlin-2 in hepatocytes using the Alb-Cre transgenic mice… read more here.
Keywords: kindlin inhibits; function; liver; kindlin loss ... See more keywords