A Brownian Ratchet Model Explains the Biased Sidestepping of Single-Headed Kinesin-3 KIF1A.
Sign Up to like & getrecommendations! Published in 2019 at "Biophysical journal"
DOI: 10.1016/j.bpj.2019.05.011
Abstract: The kinesin-3 motor KIF1A is involved in long-ranged axonal transport in neurons. To ensure vesicular delivery, motors need to navigate the microtubule lattice and overcome possible roadblocks along the way. The single-headed form of KIF1A… read more here.
Keywords: kif1a; single headed; microtubule lattice; motor ... See more keywords
MAP7D2 Localizes to the Proximal Axon and Locally Promotes Kinesin-1-Mediated Cargo Transport into the Axon
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.01.084
Abstract: Summary The motor protein kinesin-1 plays an important role in polarized sorting of transport vesicles to the axon. However, the mechanism by which the axonal entry of kinesin-1-dependent cargo transport is regulated remains unclear. Microtubule-associated… read more here.
Keywords: transport; proximal axon; promotes kinesin; kinesin ... See more keywords
Collective Force Regulation in Anti-parallel Microtubule Gliding by Dimeric Kif15 Kinesin Motors
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DOI: 10.1016/j.cub.2017.08.018
Abstract: During cell division, the mitotic kinesin-5 Eg5 generates most of the force required to separate centrosomes during spindle assembly. However, Kif15, another mitotic kinesin, can replace Eg5 function, permitting mammalian cells to acquire resistance to… read more here.
Keywords: kif15; force; parallel microtubule; kinesin ... See more keywords
Glutamylation Regulates Transport, Specializes Function, and Sculpts the Structure of Cilia
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DOI: 10.1016/j.cub.2017.09.066
Abstract: Ciliary microtubules (MTs) are extensively decorated with post-translational modifications (PTMs), such as glutamylation of tubulin tails. PTMs and tubulin isotype diversity act as a "tubulin code" that regulates cytoskeletal stability and the activity of MT-associated… read more here.
Keywords: microscopy; tubulin code; function; kinesin ... See more keywords
Coin Tossing Explains the Activity of Opposing Microtubule Motors on Phagosomes
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DOI: 10.1016/j.cub.2018.03.041
Abstract: Summary How the opposing activity of kinesin and dynein motors generates polarized distribution of organelles inside cells is poorly understood and hotly debated [1, 2]. Possible explanations include stochastic mechanical competition [3, 4], coordinated regulation… read more here.
Keywords: dynein kinesin; microtubule; coin tossing; kinesin ... See more keywords
Kinesin-5 Promotes Microtubule Nucleation and Assembly by Stabilizing a Lattice-Competent Conformation of Tubulin
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.05.075
Abstract: Besides sliding apart antiparallel microtubules during spindle elongation, the mitotic kinesin-5, Eg5, promotes microtubule polymerization, emphasizing its importance in mitotic spindle length control. Here, we characterize the Eg5 microtubule polymerase mechanism by assessing motor-induced changes… read more here.
Keywords: microtubule nucleation; conformation tubulin; promotes microtubule; kinesin ... See more keywords
Successive Kinesin-5 Microtubule Crosslinking and Sliding Promote Fast, Irreversible Formation of a Stereotyped Bipolar Spindle
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.09.030
Abstract: Separation of duplicated spindle poles is the first step in forming the mitotic spindle. Kinesin-5 crosslinks and slides anti-parallel microtubules (MTs), but it is unclear how these two activities contribute to the first steps in… read more here.
Keywords: microtubule; bipolar spindle; fast irreversible; formation ... See more keywords
The Tail of Kinesin-14a in Giardia Is a Dual Regulator of Motility
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DOI: 10.1016/j.cub.2020.06.090
Abstract: Kinesin-14s are microtubule-based motor proteins that play important roles in mitotic spindle assembly [1]. Ncd-type kinesin-14s are a subset of kinesin-14 motors that exist as homodimers with an N-terminal microtubule-binding tail, a coiled-coil central stalk… read more here.
Keywords: regulator motility; central stalk; tail; kinesin ... See more keywords
Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.10.042
Abstract: Kinesins are essential for the transport and positioning of several biomolecules through moving along the microtubule in eukaryotic cells. Up to now, there are 14 kinesin family proteins known. The MAPK pathway which is composed… read more here.
Keywords: kinesin kinesin; mapk cascade; mapk pathway; kinesin ... See more keywords
Dynamics of dimeric kinesins: Limping, effect of longitudinal force, effects of neck linker extension and mutation, and comparison between kinesin-1 and kinesin-2.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.07.147
Abstract: Conventional kinesin (kinesin-1) can walk on microtubule filaments in an asymmetric hand-over-hand manner, exhibiting a marked alternation in the mean dwell time in successive steps. Here, we study computationally the asymmetric stepping dynamics of the… read more here.
Keywords: kinesin kinesin; longitudinal force; velocity; kinesin ... See more keywords
A model of processive movement of dimeric kinesin.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2016.11.023
Abstract: Dimeric kinesin can move processively on microtubule filaments by hydrolyzing ATP. Diverse aspects of its movement dynamics have been studied extensively by using various experimental methods. However, the detailed molecular mechanism of the processive movement… read more here.
Keywords: dimeric kinesin; movement; model processive; processive movement ... See more keywords