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Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02030
Abstract: Chromosomal instability (CIN) is a hallmark of cancer that results from errors in chromosome segregation during mitosis. Targeting of CIN-associated vulnerabilities is an emerging therapeutic strategy in drug development. KIF18A, a mitotic kinesin, has been…
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Keywords:
mitotic kinesin;
kif18a;
kinesin kif18a;
chemical ... See more keywords
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3
Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4965
Abstract: Background: Chromosome instability (CIN), characterized by frequent and ongoing loss or gain of chromosome number, is commonly observed in tumor cells. Although long recognized as a vulnerability of cancer cells, potential CIN-selective therapeutic targets have…
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Keywords:
small molecule;
mitotic kinesin;
kif18a;
kinesin kif18a ... See more keywords
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Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.240986
Abstract: Regulation of proliferation, apoptosis and cell cycle is crucial for the physiology of germ cells. Their malfunction contributes to infertility and germ cell tumours. Kinesin KIF18A is an important regulator of those processes in animal…
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Keywords:
cell cycle;
germ;
germ cell;
kinesin kif18a ... See more keywords