The ubiquitous microtubule-associated protein 4 (MAP4) controls organelle distribution by regulating the activity of the kinesin motor
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206677119
Abstract: Significance Microtubules form a network spanning the interior of cells and serve as roads for molecular motor proteins that carry organelles and other cargo to where they are needed inside the cell. The function of… read more here.
Keywords: kinesin motor; motor; microtubule associated; distribution ... See more keywords
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7’s microtubule binding
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-04-0215
Abstract: The kinesin-4 motor KIF7 is a conserved regulator of the Hedgehog signaling pathway. In vertebrates, Hedgehog signaling requires the primary cilium, and KIF7 and Gli transcription factors accumulate at the cilium tip in response to… read more here.
Keywords: hedgehog; kinesin motor; kif7; microtubule binding ... See more keywords