Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16328-z
Abstract: Within the mitotic spindle, kinesin motors cross-link and slide overlapping microtubules. Some of these motors exhibit off-axis power strokes, but their impact on motility and force generation in microtubule overlaps has not been investigated. Here,… read more here.
Keywords: kinesin motors; antiparallel microtubules; microtubules around; right handed ... See more keywords
Active spiralling of microtubules driven by kinesin motors
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DOI: 10.1038/s41598-025-03384-y
Abstract: Cytoskeletal filaments propelled by surface-bound motor proteins can be viewed as active polymers, a class of active matter. When constraints are imposed on their movements, the propelled cytoskeletal filaments show dynamic patterns distinct from equilibrium… read more here.
Keywords: motor proteins; active polymers; cytoskeletal filaments; mechanics ... See more keywords
Statistical properties of autonomous flows in 2D active nematics.
Sign Up to like & getrecommendations! Published in 2019 at "Soft matter"
DOI: 10.1039/c8sm01877d
Abstract: We study the dynamics of a tunable 2D active nematic liquid crystal composed of microtubules and kinesin motors confined to an oil-water interface. Kinesin motors continuously inject mechanical energy into the system through ATP hydrolysis,… read more here.
Keywords: active nematics; kinesin motors; autonomous flows; properties autonomous ... See more keywords
Kinesin-14 motors participate in a force balance at microtubule plus-ends to regulate dynamic instability
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2108046119
Abstract: Significance Kinesin-14 motors represent an essential class of molecular motors that bind to microtubules and then walk toward the microtubule minus-end. However, whether these motors can interact with growing plus-ends of microtubules to impact the… read more here.
Keywords: kinesin motors; plus ends; microtubule plus; microtubule ... See more keywords
Mechanism of loop-2 in facilitating microtubule depolymerase activity of kinesin-8 motors
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DOI: 10.1088/1674-1056/adf4a8
Abstract: Kinesin-8 motors can move with a high processivity on microtubule lattices toward the plus end. After reaching the plus end, the kinesin-8 motors can pause for a long time and promote the microtubule depolymerization. Here,… read more here.
Keywords: depolymerase activity; microtubule; kinesin motors; kinesin ... See more keywords
Causes, costs and consequences of kinesin motors communicating through the microtubule lattice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cell Science"
DOI: 10.1242/jcs.260735
Abstract: ABSTRACT Microtubules are critical for a variety of important functions in eukaryotic cells. During intracellular trafficking, molecular motor proteins of the kinesin superfamily drive the transport of cellular cargoes by stepping processively along the microtubule… read more here.
Keywords: microtubule lattice; kinesin motors; microtubule; kinesin ... See more keywords
Kinesin-1, -2, and -3 motors use family-specific mechanochemical strategies to effectively compete with dynein during bidirectional transport
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.82228
Abstract: Bidirectional cargo transport in neurons requires competing activity of motors from the kinesin-1, -2 and -3 superfamilies against cytoplasmic dynein-1. Previous studies demonstrated that when kinesin-1 attached to dynein-dynactin-BicD2 (DDB) complex, the tethered motors move… read more here.
Keywords: bidirectional transport; cargo transport; kinesin motors; transport ... See more keywords