Using Catalysis to Drive Chemistry Away from Equilibrium: Relating Kinetic Asymmetry, Power Strokes, and the Curtin–Hammett Principle in Brownian Ratchets
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DOI: 10.1021/jacs.2c08723
Abstract: Chemically fueled autonomous molecular machines are catalysis-driven systems governed by Brownian information ratchet mechanisms. One fundamental principle behind their operation is kinetic asymmetry, which quantifies the directionality of molecular motors. However, it is difficult for… read more here.
Keywords: principle; power strokes; chemistry; kinetic asymmetry ... See more keywords
Kinetic Asymmetry versus Dissipation in the Evolution of Chemical Systems as Exemplified by Single Enzyme Chemotaxis.
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DOI: 10.1021/jacs.2c11945
Abstract: Single enzyme chemotaxis is a phenomenon by which a nonequilibrium spatial distribution of an enzyme is created and maintained by concentration gradients of the substrate and product of the catalyzed reaction. These gradients can arise… read more here.
Keywords: kinetic asymmetry; dissipation; enzyme; chemical ... See more keywords
Kinetic asymmetry allows macromolecular catalysts to drive an information ratchet
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DOI: 10.1038/s41467-019-11402-7
Abstract: Molecular machines carry out their function by equilibrium mechanical motions in environments that are far from thermodynamic equilibrium. The mechanically equilibrated character of the trajectories of the macromolecule has allowed development of a powerful theoretical… read more here.
Keywords: kinetic asymmetry; macromolecular catalysts; information ratchet; equilibrium ... See more keywords