Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00864
Abstract: Haloperidol is a typical antipsychotic drug (APD) associated with an increased risk of extrapyramidal side-effects (EPS) and hyperprolactinemia relative to atypical APDs such as clozapine. Both drugs are dopamine D2 receptor (D2R) antagonists, with contrasting… read more here.
Keywords: dopamine receptor; kinetic profiling; haloperidol; structure kinetic ... See more keywords
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
Sign Up to like & getrecommendations! Published in 2020 at "Nature Biotechnology"
DOI: 10.1038/s41587-020-0646-5
Abstract: Engineered Sp Cas9s and As Cas12a cleave fewer off-target genomic sites than wild-type (wt) Cas9. However, understanding their fidelity, mechanisms and cleavage outcomes requires systematic profiling across mispaired target DNAs. Here we describe NucleaSeq—nuclease digestion… read more here.
Keywords: cleavage; massively parallel; target; parallel kinetic ... See more keywords
Kinetic Profiling of the Hydrolytic Reaction of Benazepril: Metabolic Pathway Simulation.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of AOAC International"
DOI: 10.5740/jaoacint.17-0121
Abstract: A simple, specific, and rapid kinetic study of benazepril (BNZ) hydrolysis was developed and validated using HPLC. BNZ was degraded using 0.1 N sodium hydroxide at room temperature to produce benazeprilat, which is an active… read more here.
Keywords: profiling; hydrolytic reaction; benazepril metabolic; profiling hydrolytic ... See more keywords