Computational design of penicillin acylase variants with improved kinetic selectivity for the enzymatic synthesis of cefazolin
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2021.108149
Abstract: Abstract Enzymatic synthesis plays a pivotal role in the sustainable production of semi-synthetic β-lactam antibiotics. However, these types of green syntheses are being developed slowly because of a lack of appropriate enzymes. In the present… read more here.
Keywords: enzymatic synthesis; synthesis; kinetic selectivity; penicillin acylase ... See more keywords
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
Sign Up to like & getrecommendations! Published in 2021 at "Cell chemical biology"
DOI: 10.1016/j.chembiol.2021.01.003
Abstract: There is increasing evidence of a significant correlation between prolonged drug-target residence time and increased drug efficacy. Here, we report a structural rationale for kinetic selectivity between two closely related kinases: focal adhesion kinase (FAK)… read more here.
Keywords: kinetic selectivity; fak inhibitors; structure kinetic; selectivity ... See more keywords