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Published in 2020 at "ChemistryOpen"
DOI: 10.1002/open.202000261
Abstract: Abstract The formation of a G‐quadruplex motif in the promoter region of the c‐MYC protooncogene prevents its expression. Accordingly, G‐quadruplex stabilization by a suitable ligand may be a viable approach for anticancer therapy. In our…
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Keywords:
target guided;
guided synthesis;
molecule;
kinetic target ... See more keywords
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Published in 2020 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.0c00568
Abstract: Kinetic target-guided synthesis (KTGS) is a promising tool for the discovery of biologically active compounds. It relies on the identification of potent ligands that are covalently assembled by the biological targets themselves from a pool…
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Keywords:
guided synthesis;
target guided;
chemistry;
kinetic target ... See more keywords
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Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.3c00108
Abstract: Kinetic target-guided synthesis (KTGS) is a powerful screening approach that enables identification of small molecule modulators for biomolecules. While many KTGS variants have emerged, a majority of the examples suffer from limited throughput and a…
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Keywords:
ktgs;
guided synthesis;
kinetic target;
target guided ... See more keywords