Articles with "kinetic target" as a keyword



Photo by ggfujyoj from unsplash

Kinetic Target‐Guided Synthesis of Small‐Molecule G‐Quadruplex Stabilizers

Sign Up to like & get
recommendations!
Published in 2020 at "ChemistryOpen"

DOI: 10.1002/open.202000261

Abstract: Abstract The formation of a G‐quadruplex motif in the promoter region of the c‐MYC protooncogene prevents its expression. Accordingly, G‐quadruplex stabilization by a suitable ligand may be a viable approach for anticancer therapy. In our… read more here.

Keywords: target guided; guided synthesis; molecule; kinetic target ... See more keywords
Photo from wikipedia

Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies.

Sign Up to like & get
recommendations!
Published in 2020 at "Bioconjugate chemistry"

DOI: 10.1021/acs.bioconjchem.0c00568

Abstract: Kinetic target-guided synthesis (KTGS) is a promising tool for the discovery of biologically active compounds. It relies on the identification of potent ligands that are covalently assembled by the biological targets themselves from a pool… read more here.

Keywords: guided synthesis; target guided; chemistry; kinetic target ... See more keywords
Photo by ggfujyoj from unsplash

Going beyond Binary: Rapid Identification of Protein-Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach.

Sign Up to like & get
recommendations!
Published in 2023 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.3c00108

Abstract: Kinetic target-guided synthesis (KTGS) is a powerful screening approach that enables identification of small molecule modulators for biomolecules. While many KTGS variants have emerged, a majority of the examples suffer from limited throughput and a… read more here.

Keywords: ktgs; guided synthesis; kinetic target; target guided ... See more keywords