Kinetics of Aspartimide Formation and Hydrolysis in Lasso Peptide Lihuanodin.
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DOI: 10.1021/acs.biochem.2c00707
Abstract: Aspartimides are notorious as undesired side products in solid-phase peptide synthesis and in pharmaceutical formulations. However, we have discovered several ribosomally synthesized and post-translationally modified peptides (RiPPs) in which aspartimide is installed intentionally via enzymatic… read more here.
Keywords: lasso peptide; kinetics aspartimide; formation; peptide lihuanodin ... See more keywords