Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes
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DOI: 10.1016/j.chempr.2019.08.022
Abstract: Summary αβ-Tubulin is a validated target for anticancer drug discovery, and molecules binding to this protein are used to treat several types of tumors. Here, we report on a combined X-ray crystallography and molecular dynamics… read more here.
Keywords: residence time; thermodynamics; kinetics plinabulin; thermodynamics kinetics ... See more keywords