Kinetochore dynein is sufficient to biorient chromosomes and remodel the outer kinetochore
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-52964-5
Abstract: Multiple microtubule-directed activities concentrate on mitotic chromosomes to ensure their faithful segregation. These include couplers and dynamics regulators localized at the kinetochore, the microtubule interface built on centromeric chromatin, as well as motor proteins recruited… read more here.
Keywords: sufficient biorient; dynein; microtubule directed; biorient chromosomes ... See more keywords
The role of kinetochore dynein in checkpoint silencing is restricted to disassembly of the corona.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e23-04-0130
Abstract: During mitosis, kinetochore-microtubule attachments are monitored by a molecular surveillance system known as the spindle assembly checkpoint. The prevailing model posits that dynein evicts checkpoint proteins (e.g., Mad1, Mad2) from stably attached kinetochores by transporting… read more here.
Keywords: role; kinetochore dynein; checkpoint; microtubule ... See more keywords
Dynein at the kinetochore.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cell science"
DOI: 10.1242/jcs.220269
Abstract: The microtubule minus-end-directed motility of cytoplasmic dynein 1 (dynein), arguably the most complex and versatile cytoskeletal motor, is harnessed for diverse functions, such as long-range organelle transport in neuronal axons and spindle assembly in dividing… read more here.
Keywords: dynein kinetochore; kinetochore dynein; dynein;