Regulators of spindle microtubules and their mechanisms: Living together matters
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DOI: 10.1002/iub.1708
Abstract: Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosomes through… read more here.
Keywords: microtubule; kinetochore microtubule; mechanisms living; microtubules mechanisms ... See more keywords
Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments via the Ska Complex.
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DOI: 10.1016/j.devcel.2017.04.013
Abstract: During cell division, genome inheritance is orchestrated by microtubule attachments formed at kinetochores of mitotic chromosomes. The primary microtubule coupler at the kinetochore, the Ndc80 complex, is regulated by Aurora kinase phosphorylation of its N-terminal… read more here.
Keywords: kinetochore microtubule; ndc80 tail; microtubule attachments; tail ... See more keywords
Structure of the Ndc80 complex and its interactions at the yeast kinetochore–microtubule interface
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DOI: 10.1098/rsob.220378
Abstract: The conserved Ndc80 kinetochore complex, Ndc80c, is the principal link between spindle microtubules and centromere associated proteins during chromosome segregation. We used AlphaFold 2 to obtain structural predictions of the Ndc80 “loop” region and the… read more here.
Keywords: structure ndc80; kinetochore microtubule; microtubule interface;
The kinetochore–microtubule interface at a glance
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.214577
Abstract: ABSTRACT Accurate chromosome segregation critically depends on the formation of attachments between microtubule polymers and each sister chromatid. The kinetochore is the macromolecular complex that assembles at the centromere of each chromosome during mitosis and… read more here.
Keywords: microtubule interface; microtubule; kinetochore microtubule; glance ... See more keywords
Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments
Sign Up to like & getrecommendations! Published in 2018 at "eLife"
DOI: 10.7554/elife.36392
Abstract: Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions. Here, we present a method, based on fluorescence lifetime imaging… read more here.
Keywords: tension; kinetochore microtubule; microtubule attachments; ndc80 binding ... See more keywords