Antitumor activity of cell‐penetrant kinin B1 receptor antagonists in human triple‐negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27103
Abstract: High nuclear expression of G protein‐coupled receptors, including kinin B1 receptors (B1R), has been observed in several human cancers, but the clinical significance of this is unknown. We put forward the hypothesis that these “nuclearized”… read more here.
Keywords: breast cancer; cell penetrant; b1r; cell ... See more keywords
The kallikrein-Kinin system modulates the progression of colorectal liver metastases in a mouse model
Sign Up to like & getrecommendations! Published in 2018 at "BMC Cancer"
DOI: 10.1186/s12885-018-4260-6
Abstract: BackgroundThe Kallikrein-Kinin System (KKS) has been found to play a role in tumor progression in several cancers. The KKS metabolic cascade depends on signalling through two cross talking receptors; bradykinin receptor 1 (B1R) and bradykinin… read more here.
Keywords: kallikrein kinin; cancer; receptor; progression ... See more keywords
Kinin B1 receptor deficiency protects mice fed by cafeteria diet from abnormal glucose homeostasis
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0267845
Abstract: The kallikrein–kinin system has been implicated in body weight and glucose homeostasis. Their major effectors act by binding to the kinin B2 and B1 receptors. It was assessed the role of the kinin B1 receptor… read more here.
Keywords: b1rko; glucose homeostasis; kinin; receptor ... See more keywords
The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00234
Abstract: Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive spatial disorientation, learning and memory deficits, responsible for 60%–80% of all dementias. However, the pathological mechanism of AD remains unknown. Numerous studies revealed… read more here.
Keywords: alzheimer disease; receptors system; disease; kinin kinin ... See more keywords
The Cattle Fever Tick, Rhipicephalus microplus, as a Model for Forward Pharmacology to Elucidate Kinin GPCR Function in the Acari
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2019.01008
Abstract: The success of the acaricide amitraz, a ligand of the tick tyramine/octopamine receptor (a G protein-coupled receptor; GPCR), stimulated interest on arthropod-specific GPCRs as targets to control tick populations. This search advances tick physiology because… read more here.
Keywords: cattle fever; tick; function; pharmacology ... See more keywords
Activation of Kinin B1R Upregulates ADAM17 and Results in ACE2 Shedding in Neurons
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DOI: 10.3390/ijms22010145
Abstract: Angiotensin converting enzyme 2 (ACE2) is a critical component of the compensatory axis of the renin angiotensin system. Alterations in ACE2 gene and protein expression, and activity mediated by A Disintegrin And Metalloprotease 17 (ADAM17),… read more here.
Keywords: kinin; ace2 shedding; shedding neurons; activation ... See more keywords
Kinin B2 Receptor Activation Prevents the Evolution of Alzheimer’s Disease Pathological Characteristics in a Transgenic Mouse Model
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DOI: 10.3390/ph13100288
Abstract: Background: Alzheimer’s disease is mainly characterized by remarkable neurodegeneration in brain areas related to memory formation. This progressive neurodegeneration causes cognitive impairment, changes in behavior, functional disability, and even death. Our group has demonstrated changes… read more here.
Keywords: alzheimer disease; disease; activation; receptor ... See more keywords