Kininase I inhibition reduces B1R mediated signaling and attenuates angiotensin II-induced hypertension
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DOI: 10.1152/physiol.2023.38.s1.5730340
Abstract: Objectives: Kininase I, or carboxypeptidase M and N (CPM/CPN), metabolizes bradykinin and kallidin into endogenous kinin B1 receptor (B1R) agonists. B1R expression in the brain is linked to neuroinflammation and autonomic dysfunction, and the development… read more here.
Keywords: kininase; hypertension; b1r; cpnko mice ... See more keywords