Discovery of a Brigatinib Degrader SIAIS164018 with Destroying Metastasis-Related Oncoproteins and a Reshuffling Kinome Profile.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00373
Abstract: Proteolysis-targeting chimera (PROTAC) is an attractive technology in drug discovery. Canonically, targets act as a basic starting point in the most previous PROTAC design. Here, we designed degraders considering from the view of clinical benefits.… read more here.
Keywords: degrader siais164018; kinome; metastasis; discovery ... See more keywords
Abstract A38: Comprehensive kinome activity mapping of triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.advbc17-a38
Abstract: Triple-negative breast cancer (TNBC) accounts for around 15% of all breast cancer, with over 35,000 newly diagnosed women per year in the US. TNBC patients are at highest risk for recurrence, and neoadjuvant standard chemotherapy… read more here.
Keywords: kinome; breast cancer; cancer; activity ... See more keywords
Differential Levels of Cecal Colonization by Salmonella Enteritidis in Chickens Triggers Distinct Immune Kinome Profiles
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2017.00214
Abstract: Salmonella enterica serovar Enteritidis are facultative intracellular bacteria that cause disease in numerous species. Salmonella-related infections originating from poultry and/or poultry products are a major cause of human foodborne illness with S. Enteritidis the leading… read more here.
Keywords: salmonella; response; kinome; cecal colonization ... See more keywords
Using the Structural Kinome to Systematize Kinase Drug Discovery
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.5772/intechopen.100109
Abstract: Kinase-targeted drug design is challenging. It requires designing inhibitors that can bind to specific kinases, when all kinase catalytic domains share a common folding scaffold that binds ATP. Thus, obtaining the desired selectivity, given the… read more here.
Keywords: using structural; kinome; structural kinome; drug ... See more keywords