Millisecond dynamics of BTK reveal kinome-wide conformational plasticity within the apo kinase domain
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DOI: 10.1038/s41598-017-10697-0
Abstract: Bruton tyrosine kinase (BTK) is a key enzyme in B-cell development whose improper regulation causes severe immunodeficiency diseases. Design of selective BTK therapeutics would benefit from improved, in-silico structural modeling of the kinase’s solution ensemble.… read more here.
Keywords: wide conformational; kinase; kinase domain; millisecond ... See more keywords
GC/MS characterization and computational kinome-wide screening of pomegranate fruit extract identifies key phytochemicals interacting to CDK kinases implicated in acute myeloid leukemia cells.
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DOI: 10.1111/jfbc.14178
Abstract: Punica granatum (Pomegranate fruit) and its constituents are proven effective against various cancer types. However, a kinome-wide screening for the active phytochemicals against kinases is not reported. This study aims in validating pomegranate fruit extract… read more here.
Keywords: extract; kinome wide; pomegranate; pomegranate fruit ... See more keywords
Kinome-Wide Profiling Identifies Human WNK3 as a Target of Cajanin Stilbene Acid from Cajanus cajan (L.) Millsp.
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DOI: 10.3390/ijms23031506
Abstract: Pigeon Pea (Cajanus cajan (L.) Millsp.) is a common food crop used in many parts of the world for nutritional purposes. One of its chemical constituents is cajanin stilbene acid (CSA), which exerts anticancer activity… read more here.
Keywords: cajanin stilbene; cajan millsp; stilbene acid; kinome wide ... See more keywords