Inwardly Rectifying K+ Currents in Cultured Oligodendrocytes from Rat Optic Nerve are Insensitive to pH
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemical Research"
DOI: 10.1007/s11064-017-2242-8
Abstract: Inwardly rectifying K+ (Kir) channel expression signals at an advanced stage of maturation during oligodendroglial differentiation. Knocking down their expression halts the generation of myelin and produces severe abnormalities in the central nervous system. Kir4.1… read more here.
Keywords: kir; kir channels; currents cultured; rectifying currents ... See more keywords
KIR Genotype and KIR Ligand Phenotypes That Improve the in Vitro Cord Blood or Autologous NK Cell Mediated Cytotoxicity Against Myeloma Marrow Plasma Cells
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.395
Abstract: Instruction Killer Immunoglobulin-like Receptor (KIR) inhibition is known to influence the cytotoxic effects of natural killer (NK) cells against cancer cells. KIRs can be protective against relapse in myeloma (MM) (Gabriel et al Blood 2010,… read more here.
Keywords: kir; mediated cytotoxicity; cell mediated; blood ... See more keywords
Hematopoietic Cell Transplantation Donor Selection Reimagined: KIR-KIR Ligand Interactions and a Formalized Donor Risk Index Effective at Predicting Survival
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.569
Abstract: When selecting a human leukocyte antigen (HLA) matched unrelated donor (URD) for hematopoietic cell transplantation (HCT) it is generally accepted that donor age, sex, ABO blood group and viral serologic status should be considered. However,… read more here.
Keywords: donor; donor risk; kir; donor selection ... See more keywords
Genetic study of KIR and HLA ligands in 235 individuals from Northeastern Thailand.
Sign Up to like & getrecommendations! Published in 2017 at "Human immunology"
DOI: 10.1016/j.humimm.2017.04.002
Abstract: The diversity of 17 KIR and HLA ligands (HLA-C1, C2, Bw4, A11) were investigated in two hundred and thirty-five unrelated healthy donors in Northeastern Thais (NETs) by the polymerase chain reaction with sequence-specific primer (PCR-SSP)… read more here.
Keywords: kir; kir hla; genetic study; hla ligands ... See more keywords
P118 Presence of HLA extended haplotypes and KIR association in health and diseases in South India
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.178
Abstract: Aim To study the HLA/KIR interactions in health (HC) and disease (DC) (T1DM, T2DM, AITD, CAD, IS, PKF and AKF) cohorts with reference to two extended haplotypes (EHs). Methods Individuals with ‘DRB1∗07-DQB1∗02’ (HC = 168/1353; DC = 271/1376) and… read more here.
Keywords: kir; drb1 dqb1; south india; extended haplotypes ... See more keywords
P136 The assay for simultaneous genotyping of 14 functional KIR genes by sequence-based typing
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.196
Abstract: Aim The killer cell immunoglobulin-like receptors (KIRs) gene cluster consists of 14 functional genes and 2 pseudogenes. Identification of KIR alleles has functional and clinical significance. However, KIR sequencing-based typing (SBT) commercial kit is not… read more here.
Keywords: kir; kir genes; functional kir; pcr primers ... See more keywords
P006 NK KIR receptor genotypes are associated with relapse in mexican HLA matched sibling patients with acute lymphoblastic leukemia (ALL)
Sign Up to like & getrecommendations! Published in 2018 at "Human Immunology"
DOI: 10.1016/j.humimm.2018.07.064
Abstract: Aim The outcome of Hematopoietic Stem Cell Transplantation (HSCT) is strongly associated with the HLA identity of donor/recipient, and GVHD remains the most frequent associated factor with mortality and impact on the quality of life.… read more here.
Keywords: kir; hla; relapse; mortality ... See more keywords
CD4+CD28+KIR+CD11ahi T cells correlate with disease activity and are characterized by a pro-inflammatory epigenetic and transcriptional profile in lupus patients.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.09.011
Abstract: OBJECTIVE The goal of this study was to comprehensively characterize CD4+CD28+ T cells overexpressing CD11a and KIR genes, and examine the relationship between this T cell subset, genetic risk, and disease activity in lupus. METHODS… read more here.
Keywords: kir; cd4 cd28; lupus; cd28 kir ... See more keywords
Protective and causative killer Ig-like receptor (KIR) and metalloproteinase genetic patterns associated with Herpes simplex virus 1 (HSV-1) encephalitis occurrence
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroimmunology"
DOI: 10.1016/j.jneuroim.2020.577241
Abstract: BACKGROUND The cerebral innate immune system has a critical role in control processes of viral replication in the brain after primary infactivo and immunologic disregulation and inflammation has been reported as a primary determinant of… read more here.
Keywords: kir; acute viral; hsv; hla ... See more keywords
Significance of inhibitory maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotype combinations in placenta related obstetric complications.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reproductive immunology"
DOI: 10.1016/j.jri.2021.103425
Abstract: Some maternal killer-cell immunoglobulin-like receptor (KIR) and fetal KIR ligand genotypes are associated with obstetric complications, such as recurrent miscarriage, fetal growth restriction, preeclampsia, and preterm birth. However, how KIR/KIR ligand genotypes affect these placenta-related… read more here.
Keywords: kir; genotype; group; obstetric complications ... See more keywords
A molecular switch controls the impact of cholesterol on a Kir channel
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2109431119
Abstract: Significance Cholesterol is one of the main components found in plasma membranes and is involved in lipid-dependent signaling enabled by integral membrane proteins such as inwardly rectifying potassium (Kir) channels. Similar to other ion channels,… read more here.
Keywords: switch controls; molecular switch; controls impact; kir ... See more keywords