Understanding the genetic history of Malay populations in Peninsular Malaysia via KIR genes diversity
Sign Up to like & getrecommendations! Published in 2020 at "American Journal of Human Biology"
DOI: 10.1002/ajhb.23545
Abstract: Killer cell immunoglobulinâlike receptor (KIR) genes with high polymorphism at genotypic levels are important in providing immune defense and have been expanded towards human population genetics. The aim of this study is to provide supporting… read more here.
Keywords: kir genes; understanding genetic; genetic history; malay ... See more keywords
P136 The assay for simultaneous genotyping of 14 functional KIR genes by sequence-based typing
Sign Up to like & getrecommendations! Published in 2017 at "Human Immunology"
DOI: 10.1016/j.humimm.2017.06.196
Abstract: Aim The killer cell immunoglobulin-like receptors (KIRs) gene cluster consists of 14 functional genes and 2 pseudogenes. Identification of KIR alleles has functional and clinical significance. However, KIR sequencing-based typing (SBT) commercial kit is not… read more here.
Keywords: kir; kir genes; functional kir; pcr primers ... See more keywords
Distribution of killer cell immunoglobulin-like receptor (KIR) genes in a large, multi-centre cohort of Chinese donors
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Human Biology"
DOI: 10.1080/03014460.2021.1913223
Abstract: Abstract Background The killer cell immunoglobulin-like receptor (KIR), which mediates the killing function of NK cells, is an attractive candidate for adoptive cellular therapy. The ethnic distribution for China provides a unique opportunity to investigate… read more here.
Keywords: kir; kir genes; killer cell; cell immunoglobulin ... See more keywords
Association of Killer Cell Immunoglobulin-Like Receptors and Their HLA-Ligands with Type 1 Diabetes Among South Indian Population
Sign Up to like & getrecommendations! Published in 2023 at "Immunological Investigations"
DOI: 10.1080/08820139.2023.2165940
Abstract: ABSTRACT Background Type 1 diabetes (T1D) is a multifactorial autoimmune disease, involving strong genetic components with familial predisposition. Killer cell immunoglobulin-like receptors (KIRs) found on the surface of NK cells have ligands of human leukocyte… read more here.
Keywords: south indian; indian population; kir genes; among south ... See more keywords
Efficient and accurate KIR and HLA genotyping with massively parallel sequencing data.
Sign Up to like & getrecommendations! Published in 2023 at "Genome research"
DOI: 10.1101/gr.277585.122
Abstract: Killer immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA) genes play important roles in innate and adaptive immunity. They are highly polymorphic and cannot be genotyped with standard variant calling pipelines. Compared with HLA… read more here.
Keywords: hla; sequencing data; efficient accurate; kir ... See more keywords
Computational KIR copy number discovery reveals interaction between inhibitory receptor burden and survival
Sign Up to like & getrecommendations! Published in 2019 at "Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing"
DOI: 10.1142/9789813279827_0014
Abstract: Natural killer (NK) cells have increasingly become a target of interest for immunotherapies1. NK cells express killer immunoglobulin-like receptors (KIRs), which play a vital role in immune response to tumors by detecting cellular abnormalities. The… read more here.
Keywords: kir; kir genes; copy number; computational kir ... See more keywords
The association of HLA/KIR genes with non-small cell lung cancer (adenocarcinoma) in a Han Chinese population
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer"
DOI: 10.7150/jca.33566
Abstract: The host immune system plays a crucial role in the surveillance, recognition and elimination of tumor cells. Recent studies found that Human lymphocyte antigen class I (HLA I) genes, Killer cell immunoglobulin-like receptor (KIR) genes… read more here.
Keywords: kir genes; hla kir; cancer; cell ... See more keywords