The impact of KIR–HLA genotype on hepatitis B virus clearance in Iranian infected individuals
Sign Up to like & getrecommendations! Published in 2017 at "Medical Microbiology and Immunology"
DOI: 10.1007/s00430-017-0522-1
Abstract: Killer cell immunoglobulin like receptors (KIRs) have a principal role in regulating the effector functions of NK cells, particularly in viral infections. The major ligands for KIRs are human leukocyte antigen (HLA) class I molecules.… read more here.
Keywords: kir hla; patient groups; recovered individuals; hla ... See more keywords
Genetic study of KIR and HLA ligands in 235 individuals from Northeastern Thailand.
Sign Up to like & getrecommendations! Published in 2017 at "Human immunology"
DOI: 10.1016/j.humimm.2017.04.002
Abstract: The diversity of 17 KIR and HLA ligands (HLA-C1, C2, Bw4, A11) were investigated in two hundred and thirty-five unrelated healthy donors in Northeastern Thais (NETs) by the polymerase chain reaction with sequence-specific primer (PCR-SSP)… read more here.
Keywords: kir; kir hla; genetic study; hla ligands ... See more keywords
ERAP, KIR and HLA-C gene interaction in susceptibility to recurrent spontaneous abortion in the Polish population.
Sign Up to like & getrecommendations! Published in 2019 at "Human immunology"
DOI: 10.1016/j.humimm.2019.02.010
Abstract: Endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to generate stable antigenic epitopes for their presentation by HLA class I (HLA-I) molecules to T cell receptor. By influencing the peptide repertoire of HLA-I molecules, they… read more here.
Keywords: recurrent spontaneous; spontaneous abortion; kir hla; hla ... See more keywords
Efficient and accurate KIR and HLA genotyping with massively parallel sequencing data.
Sign Up to like & getrecommendations! Published in 2023 at "Genome research"
DOI: 10.1101/gr.277585.122
Abstract: Killer immunoglobulin-like receptor (KIR) genes and human leukocyte antigen (HLA) genes play important roles in innate and adaptive immunity. They are highly polymorphic and cannot be genotyped with standard variant calling pipelines. Compared with HLA… read more here.
Keywords: hla; sequencing data; efficient accurate; kir ... See more keywords
Immunity at maternal–fetal interface: KIR/HLA (Allo)recognition *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13087
Abstract: Both KIR and HLA are the most variable gene families in the human genome. The recognition of the semi‐allogeneic embryo‐derived trophoblasts by maternal decidual NK (dNK) cells is essential for the establishment of the functional… read more here.
Keywords: hla allo; allo recognition; kir hla; hla ... See more keywords
KIR/HLA Gene Profile Implication in Systemic Sclerosis Patients from Mexico
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunology Research"
DOI: 10.1155/2019/6808061
Abstract: Introduction Systemic Sclerosis (SSc) is an autoimmune, inflammatory, and multisystemic disease characterized by the presence of autoantibodies and fibrosis. The pathogenesis involves the interaction between immune system cells such as macrophages, NK cells, T cells,… read more here.
Keywords: systemic sclerosis; ssc patients; kir hla; gene ... See more keywords
The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/4808072
Abstract: Preeclampsia (PE) is termed as a systemic disease that involves multiple organs; however, the exact etiology is still quite unclear. It is believed that the poor remodeling of uterine spiral arteries triggers PE, thereby causing… read more here.
Keywords: kir hla; etiology; uterine natural; natural killer ... See more keywords
Allelic Polymorphisms of KIRs and HLAs Predict Favorable Responses to Tyrosine Kinase Inhibitors in CML
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Immunology Research"
DOI: 10.1158/2326-6066.cir-17-0462
Abstract: In CML patients treated with tyrosine kinase inhibitors, KIR alleles were associated with patient outcome. The combination of alleles at KIR3DL1 and HLA-B loci were found to predict the therapeutic effects of tyrosine kinase inhibitor… read more here.
Keywords: kinase inhibitors; allelic polymorphisms; kir hla; kinase ... See more keywords
Impact of KIR/HLA Incompatibilities after Posttransplant Cyclophosphamide Based T Cell-Replete Haploidentical Hematopoietic Stem Cell Transplantation
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-125243
Abstract: Introduction: Posttransplantation cyclophosphamide (PTCy) based T cell-replete haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) is a valid option for patients with indication for allogeneic HSCT without a human leucocyte antigen (HLA) matched donor. However, selection… read more here.
Keywords: cell; kir hla; hla inc; hla ... See more keywords
Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.922252
Abstract: NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic receptor family, regulating… read more here.
Keywords: hiv; hla; hla genotypes; kir hla ... See more keywords